BPG is committed to discovery and dissemination of knowledge
Articles in Press
10/20/2026 9:47:50 AM | Browse: 9 | Download: 0
| Category |
Infectious Diseases |
| Manuscript Type |
Review |
| Article Title |
Hepatitis B surface antigen-targeting strategies for clearance: A review of progress from mechanistic exploration to clinical translation
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Li Wang |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Li Wang, Associate Professor, PhD, Department of Hepatology, Yantai Qishan Hospital, No. 62 Huanshan Road, Zhifu District, Yantai 264001, Shandong Province, China. liliwang2200@163.com |
| Key Words |
Hepatitis B surface antigen clearance; Functional cure; Monoclonal antibodies; RNA interference; Gene editing; Immunoregulatory agents; Combination strategy |
| Core Tip |
Hepatitis B surface antigen persistence is the primary driver of immune tolerance in chronic hepatitis B. Strategies that reduce or eliminate hepatitis B surface antigen to break host immune tolerance and reinvigorate an immune response are emerging as promising therapeutic avenues for clinical cure. These therapeutic modalities include monoclonal antibodies, small interfering RNAs, antisense oligonucleotides, gene-editing technologies, capsid assembly modulators, agents targeting secretory pathways, and immune-based clearance strategies. Combination strategies have shown synergistic effects. Future clinical trial designs must prioritize identifying optimal combinations that maximize synergy while minimizing toxicity. |
| Citation |
Wang L. Hepatitis B surface antigen-targeting strategies for clearance: A review of progress from mechanistic exploration to clinical translation. World J Hepatol 2026; In press
|
| PDF |
125343-in-press.pdf
|
 |
Received |
|
2026-07-09 08:41 |
|
Peer-Review Started |
|
2026-07-09 08:41 |
 |
First Decision by Editorial Office Director |
|
|
|
Return for Revision |
|
2026-07-20 07:58 |
|
Revised |
|
2026-08-02 15:02 |
|
Publication Fee Transferred |
|
2026-09-17 11:26 |
|
Second Decision by Editor |
|
2026-10-19 06:06 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2026-10-20 09:47 |
|
Articles in Press |
|
2026-10-20 09:47 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
|
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
