BPG is committed to discovery and dissemination of knowledge
Articles in Press
10/8/2026 8:33:03 AM | Browse: 4 | Download: 0
| Category |
Oncology |
| Manuscript Type |
Translational Research |
| Article Title |
Plasma methylation markers for early colorectal cancer detection
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ze-Feng Liu, Jin-Hua Jiang, Wen-Jie Huang, Yue Wang, Gao-Wei Fan, Bang-Guo Chen, Zhi-En Lan, Lin-Hao Xu and Chun-Hui Cui |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 81974069 |
| the Guangdong Province Natural Science Foundation |
No. 2022A1515012587 |
| the Key Clinical Research Project of Southern Medical University |
No. LC2019ZD011 |
|
| Corresponding Author |
Chun-Hui Cui, Chief Physician, Professor, Department of Gastrointestinal Surgery, Zhujiang Hospital, Southern Medical University, No. 253 Industrial Road, Guangzhou 510282, Guangdong Province, China. drcuich@163.com |
| Key Words |
Colorectal cancer; Cell-free DNA; DNA methylation; Multiplex probe melting assay; Plasma biomarker; Early detection |
| Core Tip |
This study developed a three-marker plasma DNA methylation panel – comprising IKZF1, ITGA4, and C9orf50 – specifically designed for early detection of colorectal cancer. Leveraging multiplex probe melting assay screening, the panel effectively suppresses confounding methylation signals derived from white blood cells. It demonstrates superior diagnostic performance for colorectal cancer compared to the clinically established SEPT9 methylation blood test, achieving higher sensitivity at matched specificity and exhibiting strong potential as a noninvasive complementary diagnostic tool. |
| Citation |
Liu ZF, Jiang JH, Huang WJ, Wang Y, Fan GW, Chen BG, Lan ZE, Xu LH, Cui CH. Plasma methylation markers for early colorectal cancer detection. World J Clin Oncol 2026; In press
|
 |
Received |
|
2026-07-06 07:55 |
|
Peer-Review Started |
|
2026-07-06 07:55 |
 |
First Decision by Editorial Office Director |
|
|
|
Return for Revision |
|
2026-08-06 08:36 |
|
Revised |
|
2026-08-15 11:20 |
|
Publication Fee Transferred |
|
2026-09-10 06:29 |
|
Second Decision by Editor |
|
2026-10-08 07:09 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2026-10-08 08:33 |
|
Articles in Press |
|
2026-10-08 08:33 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
|
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
