Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	125354
DOI	10.4251/wjgo.125354
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Efficacy and mechanisms of Hedyotis diffusa-containing compound formulas for chronic atrophic gastritis with gastric intestinal metaplasia
Manuscript Source	Unsolicited Manuscript
All Author List	Qi-Yan Bian, Yu-Lian Tong, Yang-Yang Deng, Hong-Xin Zheng and Jing-Dong Xiao
Funding Agency and Grant Number	Funding Agency Grant Number 2024 National Science and Technology Major Project 2024ZD0521002 2022 National Project for the Construction of Inheritance Studios of Renowned Veteran Traditional Chinese Medicine Experts Liaoning Provincial Traditional Chinese Medicine Innovation Team
Corresponding Author	Hong-Xin Zheng, PhD, Professor, School of Basic Medical Sciences, Liaoning University of Traditional Chinese Medicine, No.79 Chongshan East Road, Shenyang 110032, Liaoning Province, China. zhenghx2002@126.com
Key Words	Hedyotis diffusa; Chronic atrophic gastritis; Gastric intestinal metaplasia; Precancerous gastric lesion; Mechanism of action
Core Tip	Compound Hedyotis diffusa (H. diffusa) formulations show initial promise in ameliorating gastric intestinal metaplasia. Mechanistic studies converge on NF-κB/NLRP3, PI3K/AKT, and Wnt/β-catenin as candidate pathways. However, the exact molecular architecture—particularly primary targets and network-level logic—remains unresolved. Most importantly, current evidence cannot distinguish H. diffusa effects from other components in multi-herb formulas.
Citation	Bian QY, Tong YL, Deng YY, Zheng HX, Xiao JD. Efficacy and mechanisms of Hedyotis diffusa-containing compound formulas for chronic atrophic gastritis with gastric intestinal metaplasia. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.125354
PDF	125354-in-press.pdf

Received	2026-07-06 09:10
Peer-Review Started	2026-07-06 09:11
First Decision by Editorial Office Director
Return for Revision	2026-08-05 05:04
Revised	2026-08-14 04:51
Publication Fee Transferred	2026-09-07 02:01
Second Decision by Editor	2026-10-22 03:01
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-22 09:14
Articles in Press	2026-10-22 09:14
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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