Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	125359
DOI	10.4240/wjgs.125359
Country	China

Category	Surgery
Manuscript Type	Basic Study
Article Title	Silencing of thrombospondin-1 prevents abdominal adhesion formation by reducing inflammation and oxidative stress
Manuscript Source	Unsolicited Manuscript
All Author List	Hao-Chongyang Tong, Chang-Chun Ye, Zhi-Xing Zhang, Wen-Hao Lin, Chao Qu, Yuan-Yuan Gao, Jia-Hao Wang, Yun-Hua Wu and Yun-Ting Liu
Funding Agency and Grant Number
Corresponding Author	Yun-Ting Liu, Department of Endoscopy Center, Shaanxi Provincial People’s Hospital, No. 256 West Youyi Road, Xi’an 710061, Shaanxi Province, China. 1529190353@qq.com
Key Words	Thrombospondin-1; Intraperitoneal adhesions; Peritoneal mesothelial cells; Reactive oxygen species; Inflammation; Mesothelial repair; Transforming growth factor beta activation; Leu-Ser-Lys-Leu peptide
Core Tip	This study identifies thrombospondin-1 (Thbs-1) as a critical driver of postsurgical intraperitoneal adhesions. We demonstrate that Thbs-1 deficiency, achieved through genetic knockdown or pharmacological inhibition with Leu-Ser-Lys-Leu, significantly attenuates adhesion formation. The underlying mechanism involves the reduction of inflammation and oxidative stress alongside the promotion of peritoneal mesothelial cell repair. By uncovering this Thbs-1-mediated pathway, our findings offer a novel therapeutic strategy to mitigate postsurgical morbidity, highlighting Thbs-1 as a promising target for clinical intervention in abdominal surgery.
Citation	Tong HCY, Ye CC, Zhang ZX, Lin WH, Qu C, Gao YY, Wang JH, Wu YH, Liu YT. Silencing of thrombospondin-1 prevents abdominal adhesion formation by reducing inflammation and oxidative stress. World J Gastrointest Surg 2026; In press DOI: https://doi.org/10.4240/wjgs.125359
PDF	125359-in-press.pdf

Received	2026-07-06 07:55
Peer-Review Started	2026-07-06 07:55
First Decision by Editorial Office Director
Return for Revision	2026-08-03 09:06
Revised	2026-08-24 03:20
Publication Fee Transferred	2026-09-19 14:28
Second Decision by Editor	2026-10-26 07:15
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-26 09:55
Articles in Press	2026-10-26 09:55
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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