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Articles in Press
10/30/2026 10:27:09 AM | Browse: 0 | Download: 0
| Category |
Orthopedics |
| Manuscript Type |
Basic Study |
| Article Title |
Single-cell RNA-sequencing analysis reveals cellular states and intercellular communication of human lumbar facet-joint degeneration
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiangyuan Chen, Wen Luo, Yuan-Zhen Chen, Lei Wang, Yue-Ying Zhang, Hui-Ying Li, Ping Wang, Zhen-Tao Man, Wei Li and Dan-Dan Wang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the National Key R&D Program of China |
No. 2022YFF0713100 |
| the Natural Science Foundation of Shandong Province |
No. ZR2026MS1334 |
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| Corresponding Author |
Dan-Dan Wang, Additional Professor, College of Clinical and Basic Medical Sciences, Shandong First Medical University and Shandong Academy of Medical Sciences, No. 6699 Qingdao Road, Huaiyin District, Jinan 250117, Shandong Province, China. ddwang@sdfmu.edu.cn |
| Key Words |
Lumbar facet joint; Osteoarthritis; Chondrocytes; Single-cell RNA sequencing; Cellular heterogeneity; Intercellular crosstalk |
| Core Tip |
This study provides a single-cell transcriptomic landscape of human lumbar facet joint (LFJ) cartilage degeneration across different degeneration stages. We identified stage-specific changes in chondrocyte and macrophage subpopulations and characterized their potential interactions during disease progression. Notably, proinflammatory chondrocytes were enriched in mild degenerated LFJs, whereas distinct macrophage populations emerged with advanced degeneration. Cell-cell communication analysis further revealed enhanced chondrocyte-macrophage crosstalk during degeneration. These findings provide new insights into the cellular heterogeneity and potential intercellular mechanisms underlying LFJ degeneration. |
| Citation |
Chen XY, Luo W, Chen YZ, Wang L, Zhang YY, Li HY, Wang P, Man ZT, Li W, Wang DD. Single-cell RNA-sequencing analysis reveals cellular states and intercellular communication of human lumbar facet-joint degeneration. World J Orthop 2026; In press
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Received |
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2026-07-06 08:12 |
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Peer-Review Started |
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2026-07-06 08:12 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-08-06 02:00 |
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Revised |
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2026-08-20 02:49 |
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Publication Fee Transferred |
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2026-09-19 13:17 |
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Second Decision by Editor |
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2026-10-30 03:06 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-10-30 10:27 |
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Articles in Press |
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2026-10-30 10:27 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
2218-5836 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
