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Articles in Press
10/12/2026 10:12:58 AM | Browse: 16 | Download: 5
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Correspondence |
| Article Title |
Letter to the editor: Causal and translational considerations for Xiangshaliujunzi decoction-mediated PANoptosis in 5-fluorouracil-resistant gastric cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yu-Yi Zhang, Yi-Ge Yu, Yan-Qi Dang and Dan Hu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Science and Technology Development Fund of Shanghai Pudong New Area |
PKJ2024-Y19 |
| the Investigator-Initiated Trial Program of Shanghai Pudong New Area Health Commission, the Cohort Study Program |
2025-PWDL-03 |
| the National Pilot Zone for Inheritance, Innovation and Development of Traditional Chinese Medicine in Pudong New Area |
PDZY-2026-0318 |
| the Science and Technology Development Project of Shanghai University of Traditional Chinese Medicine |
25KFL82 |
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| Corresponding Author |
Yan-Qi Dang, 7 LAB Joint Laboratory, Seventh People’s Hospital, Shanghai University of Traditional Chinese Medicine, No. 358 Datong Road, Pudong New Area, Shanghai 200137, China. yq_dang@shutcm.edu.cn |
| Key Words |
Gastric cancer; 5-fluorouracil resistance; PANoptosis; Xiangshaliujunzi decoction; Drug synergy; Translational validation |
| Core Tip |
Gao et al reported that Xiangshaliujunzi decoction may overcome 5-fluorouracil resistance in gastric cancer through the miR-200a-3p/ZEB1/IRF1 axis and PANoptosis-associated signaling. This letter focuses on three evidentiary levels: Mechanistic causality, pharmacological interaction, and clinical relevance. We propose pathway-specific genetic validation, standardized drug exposure with quantitative combination analysis, preparation-level characterization, and independent clinical validation. These approaches may help determine whether the proposed molecular axis represents a therapeutically actionable mechanism rather than an associated molecular signature. |
| Citation |
Zhang YY, Yu YG, Dang YQ, Hu D. Letter to the editor: Causal and translational considerations for Xiangshaliujunzi decoction-mediated PANoptosis in 5-fluorouracil-resistant gastric cancer. World J Gastrointest Oncol 2026; In press
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| PDF |
125392-in-press.pdf
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Received |
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2026-07-07 07:08 |
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Peer-Review Started |
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2026-07-07 07:08 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-08-15 16:02 |
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Revised |
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2026-08-27 22:29 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-10-12 03:05 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-10-12 10:12 |
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Articles in Press |
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2026-10-12 10:12 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
