Publication Name	World Journal of Hepatology
Manuscript ID	125393
DOI	10.4254/wjh.125393
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Correspondence
Article Title	Letter to the Editor: Diagnostic Considerations for Hepatic Sonic Hedgehog protein in Metabolic Dysfunction-Associated Steatohepatitis
Manuscript Source	Unsolicited Manuscript
All Author List	Yi-Ge Yu, Yu-Yi Zhang, Yan-Qi Dang and Dan Hu
Funding Agency and Grant Number	Funding Agency Grant Number the Shanghai Municipal Health Commission 202440017 Shanghai University of Traditional Chinese Medicine 25KFL82 National Traditional and Innovative Development of Traditional Chinese Medicine PDZY-2026-1401
Corresponding Author	Yan-Qi Dang, 7LAB Joint Laboratory, Seventh People’s Hospital, Shanghai University of Traditional Chinese Medicine, No. 358 Datong Road, Gaoqiao Town, Pudong New Area, Shanghai 200137, China. yq_dang@shutcm.edu.cn
Key Words	Metabolic dysfunction-associated steatohepatitis; Sonic hedgehog; Liver biopsy; Hepatic fibrosis; Ballooning degeneration
Core Tip	The study by Han et al. highlights the potential diagnostic value of hepatic SHH expression in MASH. Our main concern is that SHH staining was used to assist the assessment of hepatocellular ballooning, which contributes to MASH classification. This may introduce incorporation bias. Fibrosis stage may also influence the association between SHH expression and MASH. Future studies should further clarify the diagnostic value of SHH in MASH.
Citation	Yu YG, Zhang YY, Dang YQ, Hu D. Letter to the Editor: Diagnostic considerations for hepatic sonic hedgehog protein in metabolic dysfunction-associated steatohepatitis. World J Hepatol 2026; In press DOI: https://doi.org/10.4254/wjh.125393
PDF	125393-in-press.pdf

Received	2026-07-09 08:23
Peer-Review Started	2026-07-09 08:23
First Decision by Editorial Office Director
Return for Revision	2026-08-30 16:16
Revised	2026-09-13 03:57
Publication Fee Transferred
Second Decision by Editor	2026-11-13 03:28
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-13 10:23
Articles in Press	2026-11-13 10:23
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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