Publication Name	World Journal of Stem Cells
Manuscript ID	125409
DOI	10.4252/wjsc.125409
Country	China

Category	Medicine, General & Internal
Manuscript Type	Minireviews
Article Title	Lung organoids for preclinical evaluation of stem cell therapies: Opportunities, evidence, and translational challenges
Manuscript Source	Invited Manuscript
All Author List	Lu-Yu Yang, Yuan-Fang Xing, Jia-Yi Chen, Zhi-Min Cao and Huan Ye
Funding Agency and Grant Number	Funding Agency Grant Number Beijing Municipal Natural Science Foundation L234007
Corresponding Author	Huan Ye, Full Professor, MD, Professor, Department of Respiratory and Critical Care Medicine, Beijing Chest Hospital, Capital Medical University, Courtyard 1, No. 9 Beiguan Street, Tongzhou District, Beijing 101199, China. yehuan@bjxkyy.cn
Key Words	Stem cell therapy; Lung organoids; Pulmonary fibrosis; Chronic obstructive pulmonary disease; Extracellular vesicles; Disease modeling
Core Tip	Lung organoids are emerging human-relevant ex vivo models that may complement conventional preclinical systems in studying lung disease mechanisms and evaluating selected responses to stem cell-based therapeutic products. Current evidence does not support their use as clinically validated predictors of transplantation outcomes or as independent tools for comprehensive assessment of local safety-related responses. Standardized protocols and prospective studies linking organoid responses with animal and clinical outcomes are needed to establish their translational value.
Citation	Yang LY, Xing YF, Chen JY, Cao ZM, Ye H. Lung organoids for preclinical evaluation of stem cell therapies: Opportunities, evidence, and translational challenges. World J Stem Cells 2026; In press DOI: https://doi.org/10.4252/wjsc.125409
PDF	125409-in-press.pdf

Received	2026-07-14 08:33
Peer-Review Started	2026-07-14 08:33
First Decision by Editorial Office Director
Return for Revision	2026-08-05 07:53
Revised	2026-08-15 08:06
Publication Fee Transferred
Second Decision by Editor	2026-09-09 01:23
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-09-22 10:01
Articles in Press	2026-09-22 10:01
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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