Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	125464
Country	Singapore

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Carbohydrate antigen 72-4 and tumor-associated glycoprotein 72 - tumor marker: Past, present and future
Manuscript Source	Invited Manuscript
All Author List	Rui-Kyi Ng and Vishal G Shelat
Funding Agency and Grant Number
Corresponding Author	Vishal G Shelat, Adjunct Associate Professor, Department of General Surgery, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore. vgshelat@gmail.com
Key Words	Carbohydrate antigen 72-4; Tumor-associated glycoprotein 72; Gastric cancer; Tumor markers; Peritoneal carcinomatosis
Core Tip	Carbohydrate antigen 72-4 (CA72-4) refers mainly to the clinical assay or serum readout of circulating tumor-associated glycoprotein 72 (TAG-72)-related antigenic determinants; while TAG-72 refers to the broader TAG target. Gastric cancer remains the main clinical setting for CA72-4, especially in prognosis, recurrence assessment and peritoneal dissemination. Pleural-fluid CA72-4 has high specificity but modest sensitivity for malignant pleural effusion, supporting a rule-in adjunctive role. TAG-72 also links CA72-4 to cytology, immunohistochemistry, molecular imaging and cellular therapy research. Future studies should prioritize assay standardization, disease-specific thresholds, marker kinetics and patient-management outcomes.
Citation	Ng RK, Shelat VG. Carbohydrate antigen 72-4 and tumor-associated glycoprotein 72 - tumor marker: Past, present and future. World J Gastrointest Pathophysiol 2026; In press

Received	2026-07-08 08:44
Peer-Review Started	2026-07-08 08:45
First Decision by Editorial Office Director
Return for Revision	2026-07-22 13:05
Revised	2026-07-28 13:49
Publication Fee Transferred
Second Decision by Editor	2026-09-01 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-09-01 08:44
Articles in Press	2026-09-01 08:44
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2150-5330 (online)
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