Publication Name	World Journal of Hepatology
Manuscript ID	125467
Country	China

Category	Oncology
Manuscript Type	Translational Research
Article Title	Non-cancer mortality in hepatocellular carcinoma: Population-based competing-risk study
Manuscript Source	Unsolicited Manuscript
All Author List	Yi Yang, Feng Liu, Xiao-Dong Chen and Lian-Lu Jiang
Funding Agency and Grant Number
Corresponding Author	Lian-Lu Jiang, Department of Hepatobiliary, Pancreatic and Splenic Surgery, First Affiliated Hospital of Hunan College of TCM, No. 571 Renmin Middle Road, Zhuzhou 412000, Hunan Province, China. jiexiu666@gmail.com
Key Words	Hepatocellular carcinoma; Non-cancer mortality; Competing risks; Fine-Gray model; Surveillance, Epidemiology, and End Results; Time-varying effects
Core Tip	Among 31274 patients with hepatocellular carcinoma (HCC), 3880 non-HCC deaths represented 14.8% of all deaths. The proportional subdistribution hazards assumption was strongly violated, so adjusted subdistribution hazard ratios were estimated at 12 months, 36 months, and 60 months rather than summarized by one constant value. Older age remained associated with higher non-HCC mortality, whereas apparent associations for tumor burden and treatment reflected competing HCC death, patient selection, and changing risk sets. These registry associations should not be read as causal treatment effects.
Citation	Yang Y, Liu F, Chen XD, Jiang LL. Non-cancer mortality in hepatocellular carcinoma: Population-based competing-risk study. World J Hepatol 2026; In press

Received	2026-07-08 08:46
Peer-Review Started	2026-07-08 08:46
First Decision by Editorial Office Director
Return for Revision	2026-08-04 14:02
Revised	2026-08-05 05:36
Publication Fee Transferred	2026-08-18 12:40
Second Decision by Editor	2026-10-08 07:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-08 09:31
Articles in Press	2026-10-08 09:31
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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