Publication Name	World Journal of Hepatology
Manuscript ID	125487
DOI	10.4254/wjh.125487
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Treatment response in pediatric metabolic dysfunction-associated steatotic liver disease: Noninvasive endpoints and body composition
Manuscript Source	Invited Manuscript
All Author List	Toshifumi Yodoshi
Funding Agency and Grant Number
Corresponding Author	Toshifumi Yodoshi, Assistant Professor, MD, PhD, Division of Gastroenterology, Hepatology, Pancreatology and Nutrition, University of Iowa Stead Family Children’s Hospital, 200 Hawkins Drive, Iowa City, IA 52242, United States. toshifumi-yodoshi@uiowa.edu
Key Words	Metabolic dysfunction-associated steatotic liver disease; Pediatric; Treatment response; Alanine aminotransferase; Magnetic resonance imaging proton density fat fraction; Elastography; Body composition; Sarcopenic obesity; Bariatric surgery; Glucagon-like peptide-1 receptor agonist
Core Tip	Treatment response in pediatric metabolic dysfunction-associated steatotic liver disease cannot currently be defined by a single biomarker. Alanine aminotransferase, liver fat, liver stiffness, histology, cardiometabolic health, growth, body composition, and patient-reported outcomes capture complementary domains and may change at different rates. Diagnostic or prognostic performance does not by itself establish longitudinal responsiveness. This review separates those measurement properties, qualifies adult-derived thresholds, and proposes a three-tier, treatment-aware framework that distinguishes hepatic improvement with preserved muscle and normal growth from weight loss alone.
Citation	Yodoshi T. Treatment response in pediatric metabolic dysfunction-associated steatotic liver disease: Noninvasive endpoints and body composition. World J Hepatol 2026; In press DOI: https://doi.org/10.4254/wjh.125487
PDF	125487-in-press.pdf

Received	2026-07-08 08:44
Peer-Review Started	2026-07-08 08:45
First Decision by Editorial Office Director
Return for Revision	2026-08-07 01:57
Revised	2026-08-09 16:30
Publication Fee Transferred
Second Decision by Editor	2026-09-18 02:48
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-09-18 10:43
Articles in Press	2026-09-18 10:43
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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