Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	125514
DOI	10.4291/wjgp.125514
Country	Singapore

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Spleen-liver axis: An emerging framework for immunometabolic interactions across sepsis, cancer, metabolism and transplantation
Manuscript Source	Invited Manuscript
All Author List	Vishal G Shelat
Funding Agency and Grant Number
Corresponding Author	Vishal G Shelat, Adjunct Associate Professor, Department of General Surgery, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore. vgshelat@gmail.com
Key Words	Spleen-liver axis; Portal hypertension; Sepsis; Metabolic dysfunction-associated steatotic liver disease; Microbiome; Hepatocellular carcinoma; Hypersplenism; Immunometabolism
Core Tip	This minireview examines the spleen–liver axis as an emerging framework for immune, metabolic and portal-hemodynamic interactions. Direct molecular and cellular evidence is strongest for selected spleen-to-liver pathways and is predominantly preclinical. Established reverse effects are principally hemodynamic. Spleen size, stiffness and blood-based measurements may help define research phenotypes, but their added clinical value requires prospective validation. The review distinguishes these proposed applications from established portal-hypertension assessment and explains how splenic biology intersects with the gut-liver axis.
Citation	Shelat VG. Spleen-liver axis: An emerging framework for immunometabolic interactions across sepsis, cancer, metabolism and transplantation. World J Gastrointest Pathophysiol 2026; In press DOI: https://doi.org/10.4291/wjgp.125514
PDF	125514-in-press.pdf

Received	2026-07-09 05:52
Peer-Review Started	2026-07-09 05:52
First Decision by Editorial Office Director
Return for Revision	2026-08-10 02:50
Revised	2026-08-23 04:58
Publication Fee Transferred
Second Decision by Editor	2026-10-15 03:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-16 09:27
Articles in Press	2026-10-16 09:27
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2150-5330 (online)
Open Access	Open-Access: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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