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Articles in Press
10/13/2026 9:51:08 AM | Browse: 8 | Download: 1
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Minireviews |
| Article Title |
Maladaptive lipid partitioning in obesity-related heart failure with preserved ejection fraction: From depot dysfunction to metabolic phenotyping
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Si-Shang Qin, Zi-Min Wu, Bao-Shi Zheng and Cheng Luo |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Natural Science Foundation of Guangxi |
2025GXNSFAA069056 |
| the National Natural Science Foundation of China |
82360066 |
| the Guangxi Key Research and Development Program Project |
guikeAB24010153 |
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| Corresponding Author |
Cheng Luo, Assistant Professor, MD, Postdoc, Department of Cardiovascular Surgery, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Qingxiu District, Nanning 530021, Guangxi Zhuang Autonomous Region, China. drluocheng@163.com |
| Key Words |
Heart failure with preserved ejection fraction; Obesity; Lipid partitioning; Epicardial adipose tissue; Metabolic inflexibility; Body composition |
| Core Tip |
Obesity-related heart failure with preserved ejection fraction cannot be adequately characterized by body mass alone. This minireview focuses on the less frequently explored consequences of failed lipid storage: Depot-specific lipid rerouting across visceral, hepatic, skeletal muscle, epicardial/perivascular, and myocardial compartments, together with impaired myocardial substrate flexibility. We distinguish human associations from mechanistic evidence and propose adiposity-aware phenotyping as a research framework rather than a validated treatment algorithm. Recent cardiometabolic trials illustrate how complementary components of this phenotype may be therapeutically modifiable. |
| Citation |
Qin SS, Wu ZM, Zheng BS, Luo C. Maladaptive lipid partitioning in obesity-related heart failure with preserved ejection fraction: From depot dysfunction to metabolic phenotyping. World J Cardiol 2026; In press
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| PDF |
125519-in-press.pdf
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Received |
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2026-07-09 05:52 |
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Peer-Review Started |
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2026-07-09 05:52 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-08-18 01:39 |
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Revised |
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2026-09-09 16:54 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-10-13 06:01 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-10-13 09:51 |
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Articles in Press |
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2026-10-13 09:51 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
