Publication Name	World Journal of Gastroenterology
Manuscript ID	125539
DOI	10.3748/wjg.125539
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Prospective Study
Article Title	Leucine-rich alpha-2 glycoprotein reflects transmural inflammation assessed by through-the-scope endoscopic ultrasonography: A prospective study in small-bowel Crohn’s disease
Manuscript Source	Unsolicited Manuscript
All Author List	Yuan-Yuan Fang, Min Wang, Meng-Qi Huang, Ling-Yun Li, Cheng-Cheng Tian, Wei Han, Juan Wu, Pei-Pei Zhang, Qiu-Yuan Liu, Qiao Mei and Jing Hu
Funding Agency and Grant Number	Funding Agency Grant Number Research Fund of Anhui Institute of Translational Medicine No. 2023zhyx-C35
Corresponding Author	Jing Hu, PhD, Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Hefei 230022, Anhui Province, China. yfy114801@fy.ahmu.edu.cn
Key Words	Crohn’s disease; Leucine-rich alpha-2 glycoprotein; Endosonography; Transmural inflammation; Diagnostic accuracy
Core Tip	This prospective study investigated the association between serum leucine-rich alpha-2 glycoprotein (LRG) levels and transmural inflammatory activity in patients with isolated small-bowel Crohn’s disease (CD) using endoscopic ultrasonography during double-balloon enteroscopy (DBE-EUS). Serum LRG levels were strongly correlated with DBE-EUS-derived measures of transmural inflammation and demonstrated diagnostic performance comparable to fecal calprotectin and superior to C-reactive protein. Elevated LRG levels were also associated with an increased risk of CD-related rehospitalization, supporting LRG as a promising noninvasive biomarker for evaluating transmural disease activity in small-bowel CD.
Citation	Fang YY, Wang M, Huang MQ, Li LY, Tian CC, Han W, Wu J, Zhang PP, Liu QY, Mei Q, Hu J. Leucine-rich alpha-2 glycoprotein reflects transmural inflammation assessed by through-the-scope endoscopic ultrasonography: A prospective study in small-bowel Crohn’s disease. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.125539
PDF	125539-in-press.pdf

Received	2026-07-10 08:15
Peer-Review Started	2026-07-10 08:15
First Decision by Editorial Office Director
Return for Revision	2026-08-10 07:25
Revised	2026-08-21 16:37
Publication Fee Transferred	2026-09-15 11:43
Second Decision by Editor	2026-10-16 03:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-16 09:18
Articles in Press	2026-10-16 09:18
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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