Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	125580
DOI	10.4240/wjgs.125580
Country	China

Category	Surgery
Manuscript Type	Retrospective Study
Article Title	Impact of different neoadjuvant therapies on surgical complications in rectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Da-Kui Zhang, Wen-Xiao Wu, Chun-Yu Li, Wai-Ian Cheang, Zi-Han Han, Zhi-Gang Sun, Shao-Xuan Chen, Zhi-Yong Hou, Bai-Long Sun and Jian-Zheng Jie
Funding Agency and Grant Number	Funding Agency Grant Number National High Level Hospital Clinical Research Funding & Elite Medical Professionals Project of China-Japan Friendship Hospital 2025-NHLHCRF-PY-30
Corresponding Author	Jian-Zheng Jie, Chief Physician, MD, Professor, Department of Colorectal Surgery, China-Japan Friendship Hospital, No. 2 Yinghuayuan East Street, Chaoyang District, Beijing 100029, China. jianzhengjie@sohu.com
Key Words	Rectal cancer; Neoadjuvant therapy; Surgical complications; Defunctioning stoma; Anastomotic leakage
Core Tip	This retrospective study of 782 rectal cancer patients compared postoperative complications among those receiving neoadjuvant chemotherapy alone, chemoradiotherapy, or upfront surgery. Neoadjuvant therapy was associated with increased overall complications and markedly elevated anastomotic leakage risk in the absence of a defunctioning stoma. However, a defunctioning stoma reduced the leakage rates to levels comparable to those in patients without neoadjuvant treatment. Our findings emphasize that high-risk rectal cancer patients receiving neoadjuvant therapy should be actively managed with a defunctioning stoma to prevent anastomotic leakage, minimize severe surgical complications, and improve prognosis and quality of life.
Citation	Zhang DK, Wu WX, Li CY, Cheang WI, Han ZH, Sun ZG, Chen SX, Hou ZY, Sun BL, Jie JZ. Impact of different neoadjuvant therapies on surgical complications in rectal cancer. World J Gastrointest Surg 2026; In press DOI: https://doi.org/10.4240/wjgs.125580

Received	2026-07-13 08:26
Peer-Review Started	2026-07-13 08:29
First Decision by Editorial Office Director
Return for Revision	2026-08-23 08:22
Revised	2026-09-04 07:33
Publication Fee Transferred	2026-10-08 06:48
Second Decision by Editor	2026-10-30 03:06
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-30 10:27
Articles in Press	2026-10-30 10:27
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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