Publication Name	World Journal of Gastroenterology
Manuscript ID	125592
DOI	10.3748/wjg.125592
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Isoorientin attenuates Crohn’s disease-associated intestinal fibrosis by inhibiting the differentiation of inflammatory fibroblasts
Manuscript Source	Unsolicited Manuscript
All Author List	Jie Gao, Yao-Yao Liu, Lu Chen and Hong Chen
Funding Agency and Grant Number	Funding Agency Grant Number Zhongda Hospital Affiliated to Southeast University, Jiangsu Province High-Level Hospital Construction Funds YKK24268
Corresponding Author	Hong Chen, Professor, Department of Gastroenterology, Zhongda Hospital, School of Medicine, Southeast University, No. 87 Dingjiaqiao, Gulou District, Nanjing 210009, Jiangsu Province, China. njchenhong66@163.com
Key Words	Crohn’s disease; Intestinal fibrosis; Isoorientin; Single-cell RNA sequencing; Network pharmacology; Inflammatory fibroblasts
Core Tip	Intestinal fibrosis is a common complication of Crohn’s disease (CD), and there are currently no specific antifibrotic therapies. We found that isoorientin attenuates CD-associated intestinal fibrosis, potentially involving in reduced pro-inflammatory fibroblasts differentiation and decreased the expression of MMP3, MMP7 and STAT1. Our study provides new insights into CD-associated intestinal fibrosis mechanism and provides a novel, natural-product-based therapeutic strategy for managing intestinal fibrosis in inflammatory bowel disease patients.
Citation	Gao J, Liu YY, Chen L, Chen H. Isoorientin attenuates Crohn’s disease-associated intestinal fibrosis by inhibiting the differentiation of inflammatory fibroblasts. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.125592
PDF	125592-in-press.pdf

Received	2026-07-13 08:57
Peer-Review Started	2026-07-13 08:58
First Decision by Editorial Office Director
Return for Revision	2026-08-05 07:02
Revised	2026-08-18 05:39
Publication Fee Transferred	2026-09-08 08:53
Second Decision by Editor	2026-11-12 06:32
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-12 09:57
Articles in Press	2026-11-12 09:57
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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