Publication Name	World Journal of Clinical Oncology
Manuscript ID	125602
DOI	10.5306/wjco.125602
Country	China

Category	Hematology
Manuscript Type	Minireviews
Article Title	Precision medicine in diffuse large B-cell lymphoma: Integrating molecular biomarkers, targeted therapies, and prognostic tools
Manuscript Source	Invited Manuscript
All Author List	Bing-Ling Guo, Hai-Ke Lei and Yao Liu
Funding Agency and Grant Number
Corresponding Author	Yao Liu, Department of Hematology Oncology, Chongqing University Cancer Hospital, No. 181 HanYu Road, Chongqing 400030, China. liuyao77@cqu.edu.cn
Key Words	Diffuse large B-cell lymphoma; Precision medicine; molecular biomarkers; Targeted therapy; prognostic models; ctDNA; Chimeric antigen receptor T-cell therapy; Genetic subtyping; Tumor microenvironment; Immunochemotherapy
Core Tip	Diffuse large B-cell lymphoma (DLBCL) is a biologically heterogeneous disease requiring precision medicine approaches beyond standard rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone immunochemotherapy. This review synthesizes current evidence on integrating molecular subtyping (cell-of-origin and genetic subtypes), circulating tumor DNA monitoring, and tumor microenvironment characterization into clinical decision-making. We critically evaluate emerging targeted therapies including Bruton tyrosine kinase inhibitors, BCL-2 inhibitors, antibody-drug conjugates, bispecific T-cell engagers, and chimeric antigen receptor T-cell therapy. Prognostic models have evolved from the International Prognostic Index to dynamic, integrative nomograms incorporating molecular biomarkers. Challenges in standardization, cost-effectiveness, and equitable access are discussed alongside future directions for personalized DLBCL management.
Citation	Guo BL, Lei HK, Liu Y. Precision medicine in diffuse large B-cell lymphoma: Integrating molecular biomarkers, targeted therapies, and prognostic tools. World J Clin Oncol 2026; In press DOI: https://doi.org/10.5306/wjco.125602
PDF	125602-in-press.pdf

Received	2026-07-28 08:13
Peer-Review Started	2026-08-06 09:07
First Decision by Editorial Office Director
Return for Revision	2026-08-20 06:02
Revised	2026-08-26 02:20
Publication Fee Transferred
Second Decision by Editor	2026-09-20 02:51
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-09-20 11:01
Articles in Press	2026-09-20 11:01
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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