Publication Name	World Journal of Stem Cells
Manuscript ID	125616
DOI	10.4252/wjsc.125616
Country	China

Category	Cell & Tissue Engineering
Manuscript Type	Minireviews
Article Title	Potential therapeutic applications of antler stem cells and their derivatives
Manuscript Source	Invited Manuscript
All Author List	Yang He, Ji-Ping Li, Chao Ma, Guo-Kun Zhang and Chun-Yi Li
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 32300708, 32470892 Science and Technology Development Plan Project of Jilin Province YDZJ202401453ZYTS Jilin Province Medical and Health Talent Special Project 2025WSZX-JC03
Corresponding Author	Chun-Yi Li, PhD, Professor, Institute of Antler Science and Product Technology, Changchun Sci-Tech University, No. 1345 Pudong Road, Changchun 130600, Jilin Province, China. lichunyi1959@163.com
Key Words	Antler stem cells; Regeneration; Extracellular vesicles; Conditioned medium; Bone; Wound healing; Aging; Regenerative medicine
Core Tip	This review highlights antler stem cells (AnSCs) through three main points. First, it examines distinct populations, such as antler blastema progenitor cells and RXFP2-positive periosteal cells, which are related in the context of antler development and regeneration. Second, it differentiates between living-cell transplantation and cell-free derivatives, noting that the latter currently face fewer manufacturing and safety challenges. Lastly, it compares AnSCs with established mesenchymal stromal cell sources, emphasizing advantages such as strong osteochondral activity and renewable sourcing, while also tackling concerns such as immunogenicity, donor variability, and a lack of human clinical evidence.
Citation	He Y, Li JP, Ma C, Zhang GK, Li CY. Potential therapeutic applications of antler stem cells and their derivatives. World J Stem Cells 2026; In press DOI: https://doi.org/10.4252/wjsc.125616
PDF	125616-in-press.pdf

Received	2026-07-14 09:01
Peer-Review Started	2026-07-14 09:02
First Decision by Editorial Office Director
Return for Revision	2026-08-05 06:35
Revised	2026-08-18 17:19
Publication Fee Transferred
Second Decision by Editor	2026-10-08 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-20 09:34
Articles in Press	2026-10-20 09:34
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com