Publication Name	World Journal of Hepatology
Manuscript ID	125639
DOI	10.4254/wjh.125639
Country	Jordan

Category	Biochemistry & Molecular Biology
Manuscript Type	Translational Research
Article Title	Hepatocyte identity across steatosis-resolving therapies: Integrative transcriptomic and functional assessment
Manuscript Source	Unsolicited Manuscript
All Author List	Batool Mrayyan and Mustafa Salaho
Funding Agency and Grant Number
Corresponding Author	Batool Mrayyan, Researcher, Faculty of Pharmacy, Isra University, Queen Alia Airport Road, Amman 11622, Jordan. ah0406@iu.edu.jo
Key Words	Metabolic dysfunction-associated steatotic liver disease; Steatosis; Hepatocyte identity; Diacylglycerol acyltransferase 2 inhibition; Transcriptomics; Organoids; Stress pathways; Therapeutic evaluation; Functional genomics; Single-cell exploratory analysis
Core Tip	This study presents a comprehensive transcriptomic framework to evaluate steatosis-targeting therapies by analyzing steatosis-related gene modulation, hepatocyte identity, cellular stress, and donor consistency, going beyond lipid reduction alone. Among the five therapies studied, diacylglycerol acyltransferase 2 inhibition demonstrated the most favorable relative exploratory profile. We further explored the association of the diacylglycerol acyltransferase 2 inhibition-derived signature with the transcriptional state of hepatocytes by exploratory single-cell analysis. However, these results remain hypothesis-generating due to the limited number of donors, the post hoc selection of signatures, and the pseudoreplication of single cells.
Citation	Mrayyan B, Salaho M. Hepatocyte identity across steatosis-resolving therapies: Integrative transcriptomic and functional assessment. World J Hepatol 2026; In press DOI: https://doi.org/10.4254/wjh.125639
PDF	125639-in-press.pdf

Received	2026-07-16 08:22
Peer-Review Started	2026-07-16 08:23
First Decision by Editorial Office Director
Return for Revision	2026-07-29 06:02
Revised	2026-08-08 01:20
Publication Fee Transferred	2026-09-30 16:42
Second Decision by Editor	2026-10-16 03:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-16 09:07
Articles in Press	2026-10-16 09:07
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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