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Articles in Press
9/20/2026 10:52:45 AM | Browse: 21 | Download: 3
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Non-cirrhotic hyperammonemia in adults: Recognition and management
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yasmeen Obeidat and George Cholankeril |
| Funding Agency and Grant Number |
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| Corresponding Author |
Yasmeen Obeidat, Associate Professor, MD, Gastroenterology & Hepatology, Marshall University Joan C. Edwards School of Medicine, 1249 15th St, Huntington, WV 25701, United States. obeidaty@marshall.edu |
| Key Words |
Hyperammonemia; Non-cirrhotic hyperammonemia; Hepatic encephalopathy; Urea cycle disorders; Portosystemic shunt; Valproic acid; Gastric bypass; Ammonia |
| Core Tip |
In adults, a high ammonia level is usually attributed to cirrhosis, yet a substantial minority of patients have normal livers. Sorting these cases by mechanism-excess ammonia production or impaired clearance-turns a broad differential into a focused, stepwise workup. Many causes are reversible, including urease-producing infections, drugs such as valproate, portosystemic shunts, and unmasked urea cycle disorders. Measuring ammonia early in patients with unexplained encephalopathy and normal liver tests, while initiating ammonia-lowering therapy and investigating the underlying cause, can prevent avoidable brain injury. |
| Citation |
Obeidat Y, Cholankeril G. Non-cirrhotic hyperammonemia in adults: Recognition and management. World J Hepatol 2026; In press
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| PDF |
125669-in-press.pdf
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Received |
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2026-07-14 02:40 |
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Peer-Review Started |
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2026-07-14 02:41 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-08-07 02:11 |
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Revised |
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2026-08-25 16:52 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-09-20 02:51 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-09-20 10:52 |
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Articles in Press |
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2026-09-20 10:52 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
