Publication Name	World Journal of Stem Cells
Manuscript ID	125673
DOI	10.4252/wjsc.125673
Country	Iraq

Category	Immunology
Manuscript Type	Minireviews
Article Title	Soluble immunosuppressive checkpointome of mesenchymal stromal cells: Immunoregulatory mechanisms and a conceptual framework for potency assessment
Manuscript Source	Invited Manuscript
All Author List	Abdullah Salim Al-Karawi and Ali Saad Al-Budairi
Funding Agency and Grant Number
Corresponding Author	Abdullah Salim Al-Karawi, Researcher, Department of Microbiology, College of Science, Mustansiriyah University, Baghdad 0011, Iraq. abdullah.s.shaker@uomustansiriyah.edu.iq
Key Words	Mesenchymal stromal cells; Soluble immune checkpoints; Programmed death ligand 1; Galectin-9; Human leukocyte antigen-G5; Potency assay; Cell therapy; Immunomodulation
Core Tip	Mesenchymal stromal cells release a defined set of soluble immune checkpoint proteins, notably soluble programmed death ligand 1 and 2, galectin-9, galectin-1 and the secreted human leukocyte antigen-G5 isoform. Treated separately until now, they form a single inducible module we term the soluble checkpointome. Because its abundance rises with inflammatory licensing and tracks with suppressive capacity, it offers a licensed, cell-free, multi-analyte panel well suited to the potency assays regulators require, and amenable to composite scoring supported by machine learning.
Citation	Al-Karawi AS, Al-Budairi AS. Soluble immunosuppressive checkpointome of mesenchymal stromal cells: Immunoregulatory mechanisms and a conceptual framework for potency assessment. World J Stem Cells 2026; In press DOI: https://doi.org/10.4252/wjsc.125673
PDF	125673-in-press.pdf

Received	2026-07-15 08:49
Peer-Review Started	2026-07-15 08:49
First Decision by Editorial Office Director
Return for Revision	2026-09-04 03:07
Revised	2026-09-07 20:49
Publication Fee Transferred
Second Decision by Editor	2026-10-13 05:55
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-20 09:35
Articles in Press	2026-10-20 09:35
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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