Publication Name	World Journal of Diabetes
Manuscript ID	125698
DOI	10.4239/wjd.125698
Country	China

Category	Medicine, Research & Experimental
Manuscript Type	Retrospective Study
Article Title	Integrating traditional Chinese medicine syndromes with clinical variables to predict lower extremity arterial disease in type 2 diabetes
Manuscript Source	Unsolicited Manuscript
All Author List	Ying-Wei Lv, Ai-Juan Jiang, Yu-Meng Geng, Min Hu, Yu-Qing Wang, Lin Ma, Nuo Shen and Jin-Dong Zhao
Funding Agency and Grant Number	Funding Agency Grant Number Anhui Provincial Natural Science Foundation Project 2308085MH307 The "Basic-Clinical Integration" Special Project of Category A for 2025 of Anhui University of Chinese Medicine JCLCA2025024 National Natural Science Foundation of China 82505372
Corresponding Author	Ai-Juan Jiang, PhD, Professor, Graduate School, Anhui University of Chinese Medicine, 350 Longzihu Road, Xinhua High-tech Zone, Hefei City, Anhui Province, P.R.China, Hefei 230012, Anhui Province, China. jiangaijuan@ahtcm.edu.cn
Key Words	Machine learning; Diabetic lower extremity arterial disease; Integrated Chinese and Western medicine; Prediction model; XGBoost; Nomogram
Core Tip	This study integrated Western medicine demographic and clinical characteristics, laboratory indicators, and traditional Chinese medicine syndrome features to construct prediction models for lower extremity arterial disease (LEAD) in type 2 diabetes mellitus using multiple machine learning algorithms. The XGBoost model based on integrated Western and Chinese medicine features exhibited the highest efficacy and has potential for the early identification and treatment of LEAD.
Citation	Lv YW, Jiang AJ, Geng YM, Hu M, Wang YQ, Ma L, Shen N, Zhao JD. Integrating traditional Chinese medicine syndromes with clinical variables to predict lower extremity arterial disease in type 2 diabetes. World J Diabetes 2026; In press DOI: https://doi.org/10.4239/wjd.125698
PDF	125698-in-press.pdf

Received	2026-07-14 02:52
Peer-Review Started	2026-07-14 23:58
First Decision by Editorial Office Director
Return for Revision	2026-08-06 08:59
Revised	2026-08-09 16:05
Publication Fee Transferred	2026-09-07 02:33
Second Decision by Editor	2026-09-21 02:06
Second Decision by Editor-in-Chief	2026-09-21 04:53
Final Decision by Editorial Office Director	2026-10-09 09:42
Articles in Press	2026-10-09 09:42
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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