BPG is committed to discovery and dissemination of knowledge
Articles in Press
11/10/2026 10:15:53 AM | Browse: 12 | Download: 0
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Ubiquitin-specific protease 15 promotes the progression of pancreatic ductal adenocarcinoma by regulating discoidin domain receptor 1 ubiquitination and degradation
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yu-Bo Liu, Xing-Bo Wei, Hua Fan, Yan Chen, Chen-Shuo Zhang, Chi Zhang and Yan-Hui Yang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Natural Science Foundation of Henan Province (General Program) |
262300421559 |
| the Science and Technology Research Project of the First Affiliated Hospital of Henan University of Science and Technology |
ZLKFFJJ20230409 |
|
| Corresponding Author |
Yan-Hui Yang, Affiliate Associate Professor, Department of Emergency Medicine, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, No. 24 Jinghua Road, Luoyang 471003, Henan Province, China. yangyanhui63@163.com |
| Key Words |
Ubiquitin-specific protease 15; Discoidin domain receptor 1; Deubiquitination; Pancreatic ductal adenocarcinoma; Proteasomal degradation; Prognosis |
| Core Tip |
This study reveals for the first time that the deubiquitinase ubiquitin-specific protease (USP15) targets discoidin domain receptor 1 (DDR1) to remove ubiquitin chains, inhibiting proteasome mediated degradation and thereby maintaining DDR1 protein stability and promoting pancreatic cancer malignancy. The USP15-DDR1 axis represents a potential therapeutic target for pancreatic ductal adenocarcinoma. |
| Citation |
Liu YB, Wei XB, Fan H, Chen Y, Zhang CS, Zhang C, Yang YH. Ubiquitin-specific protease 15 promotes the progression of pancreatic ductal adenocarcinoma by regulating discoidin domain receptor 1 ubiquitination and degradation. World J Gastrointest Oncol 2026; In press
|
 |
Received |
|
2026-07-20 09:01 |
|
Peer-Review Started |
|
2026-07-20 09:02 |
 |
First Decision by Editorial Office Director |
|
|
|
Return for Revision |
|
2026-08-13 13:01 |
|
Revised |
|
2026-08-25 09:55 |
|
Publication Fee Transferred |
|
2026-09-24 09:06 |
|
Second Decision by Editor |
|
2026-11-10 03:44 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2026-11-10 10:15 |
|
Articles in Press |
|
2026-11-10 10:15 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
|
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
