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Articles in Press
11/4/2026 10:29:08 AM | Browse: 12 | Download: 3
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Clinical Trials Study |
| Article Title |
Low-dose remimazolam plus remifentanil vs placebo plus remifentanil during gastroscopy in adults with obesity: A randomized trial
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiao-Jing Dai, Zi-Jie Bian, Lian-Yi Zhang, Man-Ting Zhao and Ying Yang |
| Funding Agency and Grant Number |
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| Corresponding Author |
Ying Yang, Department of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, No. 99 Huaihai West Road, Quanshan District, Xuzhou 221000, Jiangsu Province, China. 17712981251@163.com |
| Key Words |
Remimazolam; Remifentanil; Obesity; Gastroscopy; Procedural sedation; Randomized controlled trial |
| Core Tip |
In adults with obesity undergoing gastroscopy, adding low-dose remimazolam to remifentanil increased successful insertion without body movement, coughing, or retching from 63.5% to 81.5% and reduced rescue remifentanil use from 48.1% to 13.0% in the modified intention-to-treat analysis. Sensitivity analyses in all 110 randomized participants showed a consistent direction of effect. Case-report form-recorded desaturation was more frequent with the combined regimen, whereas scheduled four-time-point oxygenation was similar between groups and protocol-defined hypoxemia and mask ventilation were uncommon. These findings suggest improved procedural tolerance while underscoring the importance of close respiratory monitoring. |
| Citation |
Dai XJ, Bian ZJ, Zhang LY, Zhao MT, Yang Y. Low-dose remimazolam plus remifentanil vs placebo plus remifentanil during gastroscopy in adults with obesity: A randomized trial. World J Gastrointest Surg 2026; In press
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| PDF |
125799-in-press.pdf
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Received |
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2026-07-22 08:12 |
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Peer-Review Started |
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2026-07-22 08:13 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-08-11 08:44 |
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Revised |
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2026-08-26 07:25 |
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Publication Fee Transferred |
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2026-09-30 02:17 |
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Second Decision by Editor |
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2026-11-02 02:18 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-11-04 10:29 |
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Articles in Press |
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2026-11-04 10:29 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
