Publication Name	World Journal of Diabetes
Manuscript ID	125802
Country	China

Category	Medicine, General & Internal
Manuscript Type	Minireviews
Article Title	Centrosome amplification in type 2 diabetes mellitus: Putative mechanisms, clinical research implications, and investigational therapeutic perspectives
Manuscript Source	Unsolicited Manuscript
All Author List	Yan-Hua Zhang, Zhi-Zhou Song and Sheng Zhang
Funding Agency and Grant Number
Corresponding Author	Sheng Zhang, Chief Pharmacist, Department of Cardiology, The Third People’s Hospital of Datong, No. 43 Wenchang Street, Pingcheng District, Datong 037000, Shanxi Province, China. zhangshengxy3@csu.edu.cn
Key Words	Centrosome; Centrosome amplification; Type 2 diabetes mellitus; Pancreatic β-cell; Insulin resistance; Diabetic complications; Biomarkers; Oxidative stress; Rho-associated protein kinase 1
Core Tip	In vitro studies indicate that the diabetic microenvironment can induce Centrosome amplification (CA) via multiple interconnected signalling cascades, including protein kinase B-reactive oxygen species(Rho-associated coiled-coil-containing protein kinase 1/14-3-3 protein sigma, Wnt6-frizzled 4, protein kinase C-p38 and peroxisome proliferator-activated receptor γ-spindle and kinetochore-associated protein 1 axes. Putative links between CA and pancreatic β-cell failure, systemic insulin resistance, as well as diabetic macro-and microvascular complications remain largely hypothetical, owing to limited direct in vivo evidence from human metabolic tissues. Peripheral-blood-mononuclear-cell CA correlates with glycated haemoglobin and complication severity within a single observational clinical cohort; these associations cannot support prognostic inference, and it remains purely an exploratory research biomarker and is not ready for clinical application. Modulation of centrosome homeostasis represents a preclinical investigational direction; therapeutic benefits of polo-like kinase 4 inhibitors, Rho-associated coiled-coil-containing protein kinase blockers and antidiabetic agents related to CA suppression still await formal experimental verification.
Citation	Zhang YH, Song ZZ, Zhang S. Centrosome amplification in type 2 diabetes mellitus: Putative mechanisms, clinical research implications, and investigational therapeutic perspectives. World J Diabetes 2026; In press

Received	2026-07-17 07:03
Peer-Review Started	2026-07-20 00:10
First Decision by Editorial Office Director
Return for Revision	2026-08-03 08:08
Revised	2026-08-15 16:05
Publication Fee Transferred	2026-08-28 15:55
Second Decision by Editor	2026-09-20 02:45
Second Decision by Editor-in-Chief	2026-09-20 03:39
Final Decision by Editorial Office Director	2026-10-08 08:58
Articles in Press	2026-10-08 08:58
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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