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Articles in Press
10/29/2026 10:25:05 AM | Browse: 2 | Download: 1
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Chromatin assembly factor 1 subunit B expression correlates with favorable prognosis and potential therapeutic response prediction in left-sided colorectal cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xi-Jie Fan, Fu-Sheng Wang, Yuan Yao, Shun Xu, Chao-Qian Chen and Zong-Xian Zhao |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Fuyang Municipal Science and Technology Bureau, Anhui, China |
No. FK20245505 |
| Anhui Provincial Health Commission |
No. AHWJ2023Baa20164 |
| Bengbu Medical University |
No. 2022byzd168 |
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| Corresponding Author |
Zong-Xian Zhao, Department of Anorectal Surgery, Fuyang City People’s Hospital, No. 501 Sanqing Road, Yingzhou District, Fuyang 236000, Anhui Province, China. 461901580@qq.com |
| Key Words |
Chromatin assembly factor 1 subunit B; Left colorectal cancer; Immunotherapy; Chemosensitivity; Biomarker; Prognosis |
| Core Tip |
Accumulating evidence supports the notion that left-side colorectal cancer (CRC) and right-sided CRC represent distinct disease entities. Precise molecular subtyping of CRC is therefore an urgent unmet need to enable individualized precision treatment. Currently, the biological function of chromatin assembly factor 1 subunit B (CHAF1B) in CRC remains largely uncharacterized. In this study, elevated CHAF1B was an independent favorable prognostic biomarker for left-side CRC patients and correlated with enhanced cellular sensitivity to first-line chemotherapeutic agents. High CHAF1B expression was significantly associated with microsatellite instability-high status and high tumor mutational burden, as well as potential favorable therapeutic outcomes in patients receiving immunotherapy. |
| Citation |
Fan XJ, Wang FS, Yao Y, Xu S, Chen CQ, Zhao ZX. Chromatin assembly factor 1 subunit B expression correlates with favorable prognosis and potential therapeutic response prediction in left-sided colorectal cancer. World J Gastrointest Oncol 2026; In press
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| PDF |
125841-in-press.pdf
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Received |
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2026-07-20 06:33 |
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Peer-Review Started |
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2026-07-20 06:34 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-08-10 05:48 |
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Revised |
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2026-08-22 02:49 |
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Publication Fee Transferred |
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2026-09-07 10:20 |
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Second Decision by Editor |
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2026-10-29 07:08 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-10-29 10:25 |
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Articles in Press |
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2026-10-29 10:25 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
