Publication Name	World Journal of Clinical Oncology
Manuscript ID	125846
Country	China

Category	Biology
Manuscript Type	Minireviews
Article Title	Vitamin-mediated cancer immune reprogramming: Context-dependent mechanisms and translational perspectives
Manuscript Source	Invited Manuscript
All Author List	Qian Zhang, Rong-Hao Yang, Xiao-Rui An and Hao-Cai Chang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 62475076 Guangdong Provincial Department of Education Key Areas Special Project for Regular Higher Education Institutions 2023ZDZX2022 Youth S&T Talent Support Programme of Guangdong Provincial Association for Science and Technology SKXRC2025014
Corresponding Author	Hao-Cai Chang, Assistant Professor, PhD, MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, School of Optoelectronic Science and Engineering, South China Normal University, No. 55 West Zhongshan Avenue, Tianhe District, Guangzhou 510631, Guangdong Province, China. changhc@scnu.edu.cn
Key Words	Vitamins; Immunometabolism; Tumor microenvironment; Immune checkpoint inhibitor therapy; Dendritic cells; Natural killer cells; Precision vitamin immunotherapy
Core Tip	Vitamins are context-dependent immunometabolic regulators reshaping anti-tumor immunity and immune checkpoint inhibitor response beyond simple antioxidant function. This review summarizes mechanistic and translational evidence of vitamins A/B/C/D/E/K in tumor immunity, putting forward three core principles covering dose-dependent immune effects, epigenetic regulatory mechanisms, and biomarker-guided adjuvant application. We propose a precision vitamin-targeted immunotherapy framework combining deficiency correction, standardized supplementation and matched immune background to optimize tumor immunotherapy efficacy.
Citation	Zhang Q, Yang RH, An XR, Chang HC. Vitamin-mediated cancer immune reprogramming: Context-dependent mechanisms and translational perspectives. World J Clin Oncol 2026; In press

Received	2026-07-20 09:15
Peer-Review Started	2026-07-20 09:16
First Decision by Editorial Office Director
Return for Revision	2026-08-04 07:09
Revised	2026-08-22 17:22
Publication Fee Transferred
Second Decision by Editor	2026-10-08 07:09
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-08 08:35
Articles in Press	2026-10-08 08:35
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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