Publication Name	World Journal of Clinical Oncology
Manuscript ID	125850
DOI	10.5306/wjco.125850
Country	China

Category	Oncology
Manuscript Type	Review
Article Title	Immune-cell source in patient-derived tumor organoid co-cultures: Methodological choices and clinical interpretation in precision immuno-oncology
Manuscript Source	Invited Manuscript
All Author List	Yi-Rong Wang, Ye Zhang, Shi-Qin Yang, Ting-Ting Zhang and Yao-Qi Lu
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of the Jiangsu Higher Education Institutions of China 25KJB310013
Corresponding Author	Yao-Qi Lu, Lecturer, PhD, School of Biomedicine and Pharmacy, Suzhou Chien-shiung Institute of Technology, No. 1 Jianxiong Road, Science and Education New Town, Suzhou 215411, Jiangsu Province, China. yaoqilu16@163.com
Key Words	Patient-derived organoids; Tumor organoids; Immune co-culture; Peripheral blood mononuclear cells; Tumor-infiltrating lymphocytes; Chimeric antigen receptor-T cells; Precision immuno-oncology; Tumor microenvironment
Core Tip	An immune co-culture is not defined by cell source alone. Origin, donor relationship, lineage, recognition mechanism, processing, culture format, timing, endpoint, and intended use jointly determine what the experiment measures and how far its findings can be carried into clinical interpretation.
Citation	Wang YR, Zhang Y, Yang SQ, Zhang TT, Lu YQ. Immune-cell source in patient-derived tumor organoid co-cultures: Methodological choices and clinical interpretation in precision immuno-oncology. World J Clin Oncol 2026; In press DOI: https://doi.org/10.5306/wjco.125850
PDF	125850-in-press.pdf

Received	2026-07-20 09:15
Peer-Review Started	2026-07-20 09:16
First Decision by Editorial Office Director
Return for Revision	2026-08-28 07:32
Revised	2026-09-04 05:36
Publication Fee Transferred
Second Decision by Editor	2026-10-29 07:08
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-29 10:29
Articles in Press	2026-10-29 10:29
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
Open Access	Open-Access: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com