Publication Name	World Journal of Stem Cells
Manuscript ID	125852
DOI	10.4252/wjsc.125852
Country	Italy

Category	Ophthalmology
Manuscript Type	Minireviews
Article Title	Stem cell secretome- and extracellular vesicle-based therapies for retinal pathologies
Manuscript Source	Invited Manuscript
All Author List	Matteo Capobianco, Francesco Cappellani, Ehimare S Enaholo and Marco Zeppieri
Funding Agency and Grant Number
Corresponding Author	Marco Zeppieri, Consultant, MD, PhD, Postdoc, Department of Ophthalmology, University Hospital of Udine, p. le S. Maria della Misericordia 15, Udine 33100, Italy. mark.zeppieri@asufc.sanita.fvg.it
Key Words	Stem cell secretome; Retinal degeneration; Exosomes; Regenerative medicine; Extracellular vesicles
Core Tip	Stem cell secretome and extracellular vesicles are under exploration as acellular therapeutic approaches for retinal disease. Their biological activity appears to depend largely on the transfer of trophic factors, proteins, lipids, and regulatory RNAs that can influence inflammation, oxidative stress, apoptosis, vascular homeostasis, and neuronal survival. Although the findings reported to date are encouraging, most of the available evidence remains preclinical. Before these products can enter routine retinal care, substantial work is still needed to standardize their production and characterization, define appropriate dosing, establish reliable potency assays, and assess long-term safety.
Citation	Capobianco M, Cappellani F, Enaholo ES, Zeppieri M. Stem cell secretome- and extracellular vesicle-based therapies for retinal pathologies. World J Stem Cells 2026; In press DOI: https://doi.org/10.4252/wjsc.125852
PDF	125852-in-press.pdf

Received	2026-07-20 09:01
Peer-Review Started	2026-07-20 09:02
First Decision by Editorial Office Director
Return for Revision	2026-08-24 09:09
Revised	2026-08-24 17:03
Publication Fee Transferred
Second Decision by Editor	2026-10-12 00:49
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-20 09:35
Articles in Press	2026-10-20 09:35
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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