Publication Name	World Journal of Gastroenterology
Manuscript ID	125902
DOI	10.3748/wjg.125902
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Clinical and therapeutic management of gastrointestinal polyp-related complications in Peutz-Jeghers syndrome: A narrative review
Manuscript Source	Unsolicited Manuscript
All Author List	Yang-Ping Zheng, Xin-Yun Yang, Jia-Hui Ding, Shi-Hai He, Zhi-Qing Li, Chen-Jing Zhang and Wen-Sheng Pan
Funding Agency and Grant Number
Corresponding Author	Wen-Sheng Pan, Doctorate Student, Full Professor, Professor, Department of Gastroenterology, Zhejiang Provincial People’s Hospital, No. 158 Shangtang Road, Gongshu District, Hangzhou 310014, Zhejiang Province, China. panwensheng@hmc.edu.cn
Key Words	Peutz-Jeghers syndrome; Gastrointestinal polyps; Intussusception; Balloon-assisted enteroscopy; Gastrointestinal bleeding; Endoscopic polypectomy; Surveillance
Core Tip	Peutz-Jeghers syndrome is characterized by gastrointestinal hamartomatous polyps that can cause intussusception, bowel obstruction, gastrointestinal bleeding, anemia, and repeated surgery. This article summarizes current evidence on the mechanisms, clinical manifestations, surveillance, and management of polyp-related complications. Particular emphasis is placed on balloon-assisted enteroscopy, endoscopic polypectomy, ischemic polypectomy, and bowel-preserving strategies. Early surveillance and timely removal of clinically significant polyps may reduce acute complications and preserve intestinal length. Emerging pharmacological approaches remain investigational, highlighting the need for prospective multicenter studies and individualized surveillance strategies.
Citation	Zheng YP, Yang XY, Ding JH, He SH, Li ZQ, Zhang CJ, Pan WS. Clinical and therapeutic management of gastrointestinal polyp-related complications in Peutz-Jeghers syndrome: A narrative review. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.125902
PDF	125902-in-press.pdf

Received	2026-07-23 08:46
Peer-Review Started	2026-07-23 08:46
First Decision by Editorial Office Director
Return for Revision	2026-08-31 03:15
Revised	2026-09-09 13:19
Publication Fee Transferred	2026-09-15 22:48
Second Decision by Editor	2026-11-02 02:18
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-04 10:42
Articles in Press	2026-11-04 10:42
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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