Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	125907
DOI	10.4251/wjgo.125907
Country	China

Category	Oncology
Manuscript Type	Minireviews
Article Title	From radiomics to habitat imaging and topological heterogeneity: Imaging-based tumor heterogeneity analysis in gastrointestinal oncology
Manuscript Source	Invited Manuscript
All Author List	Zhi-Chao Zuo
Funding Agency and Grant Number
Corresponding Author	Zhi-Chao Zuo, PhD, Department of Radiology, The Central Hospital of Xiangtan, The Affiliated Hospital of Hunan University, No. 120 Heping Road, Xiangtan 411000, Hunan Province, China. zuo_z@smail.xtu.edu.cn
Key Words	Intratumoral heterogeneity; Radiomics; Habitat imaging; Topological data analysis; Persistent homology; Gastric cancer; Colorectal cancer; Hepatocellular carcinoma; Pancreatic ductal adenocarcinoma; Esophageal cancer
Core Tip	Global radiomics, habitat imaging, and topology-informed analysis are complementary rather than successive methods. They ask what overall phenotype a tumor has, which spatially distinct subregions are present, and how local phenotypes are organized. This review uses a distribution-localization-organization framework to map the evidence across major gastrointestinal cancers. Clinical translation depends on reproducibility, biological anchoring, incremental value, and prospective decision impact rather than on discrimination alone.
Citation	Zuo ZC. From radiomics to habitat imaging and topological heterogeneity: Imaging-based tumor heterogeneity analysis in gastrointestinal oncology. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.125907
PDF	125907-in-press.pdf

Received	2026-07-21 11:21
Peer-Review Started	2026-07-21 11:21
First Decision by Editorial Office Director
Return for Revision	2026-08-27 02:40
Revised	2026-09-01 10:19
Publication Fee Transferred
Second Decision by Editor	2026-11-02 02:18
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-04 10:28
Articles in Press	2026-11-04 10:28
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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