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Articles in Press
11/4/2026 10:42:55 AM | Browse: 15 | Download: 3
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Prognostic significance of human epidermal growth factor receptor 2 in gastric signet-ring cell carcinoma: Neoadjuvant chemotherapy interaction study
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Peng Wang, Qi Zhang, Xu Liu, Yu-Juan Jiang, Quan Xu and You-Gang Cui |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the CAMS Innovation Fund for Medical Sciences |
No. 2025-I2M-C&T-B-060 |
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| Corresponding Author |
You-Gang Cui, Department of Gastrointestinal Surgery, Affiliated Zhongshan Hospital of Dalian University, No. 6 Jiefang Street, Zhongshan District, Dalian 116000, Liaoning Province, China. cuiyougang@163.com |
| Key Words |
Gastric signet-ring cell carcinoma; Human epidermal growth factor receptor 2 status; Human epidermal growth factor receptor 2-low expression; Prognosis; Neoadjuvant chemotherapy |
| Core Tip |
Human epidermal growth factor receptor 2 (HER2) positivity was independently associated with poor prognosis in gastric signet-ring cell carcinoma. A significant interaction between HER2 status and neoadjuvant chemotherapy (NAC) was observed in the overall cohort. Propensity score-matched analyses showed that the associations between NAC and poorer survival persisted in the HER2-negative and HER2-low subgroups after adjustment for measured treatment-selection factors. However, the association in the HER2-positive subgroup could not be reliably evaluated because only two patients received NAC. These findings should be considered exploratory and warrant prospective validation. |
| Citation |
Wang P, Zhang Q, Liu X, Jiang YJ, Xu Q, Cui YG. Prognostic significance of human epidermal growth factor receptor 2 in gastric signet-ring cell carcinoma: Neoadjuvant chemotherapy interaction study. World J Gastroenterol 2026; In press
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| PDF |
125908-in-press.pdf
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Received |
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2026-07-23 01:36 |
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Peer-Review Started |
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2026-07-23 01:36 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-08-19 04:47 |
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Revised |
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2026-09-03 03:12 |
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Publication Fee Transferred |
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2026-09-18 13:52 |
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Second Decision by Editor |
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2026-11-02 02:18 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-11-04 10:42 |
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Articles in Press |
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2026-11-04 10:42 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
