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Publication Name World Journal of Gastroenterology
Manuscript ID 125931
Country China
Category Gastroenterology & Hepatology
Manuscript Type Meta-Analysis
Article Title Comparison of efficacy and safety of different treatment modalities for hemorrhoids: A network meta-analysis
Manuscript Source Unsolicited Manuscript
All Author List Bin Chen, Xin-Ru Xiong, Zhen-Guo Zhang and Qing-Qing Chen
Funding Agency and Grant Number
Corresponding Author Bin Chen, PhD, Department of Proctology, The Second Hospital of Yinzhou, No. 998 at Qianhebei Road, Department of Proctology, The Second Hospital of Yinzhou, Yinzhou District, Ningbo, Zhejiang Province, 315100, China, Ningbo 315100, Zhejiang Province, China. chenbin031212@yeah.net
Key Words Hemorrhoids; Network meta-analysis; Hemorrhoidectomy; Recurrence; Complication
Core Tip This network meta-analysis of 66 randomized controlled trials involving 8549 patients compares 20 therapeutic modalities for hemorrhoidal disease. LigaSureTM hemorrhoidectomy and tissue-selecting technique demonstrate the most favorable balance between recurrence control and safety, particularly in severe (grade ≥ III) disease. Rubber band ligation and injection sclerotherapy, though safer, carry substantially higher recurrence risks and are best suited for mild disease or non-surgical candidates. Treatment decisions should be individualized, with grade-based recommendations considered exploratory.
Citation Chen B, Xiong XR, Zhang ZG, Chen QQ. Comparison of efficacy and safety of different treatment modalities for hemorrhoids: A network meta-analysis. World J Gastroenterol 2026; In press
Received
2026-07-21 10:40
Peer-Review Started
2026-07-21 10:40
First Decision by Editorial Office Director
Return for Revision
2026-08-04 01:24
Revised
2026-08-10 02:10
Publication Fee Transferred
Second Decision by Editor
2026-10-08 07:09
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-10-08 09:09
Articles in Press
2026-10-08 09:09
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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