Publication Name	World Journal of Translational Medicine
Manuscript ID	125988
DOI	10.5528/wjtm.125988
Country	Malaysia

Category	Cell Biology
Manuscript Type	Minireviews
Article Title	Adenosine triphosphate homeostasis in cardiovascular cell-fate transitions: Adenosine triphosphate-induced cellular senescence and adenosine triphosphate-induced cell death
Manuscript Source	Invited Manuscript
All Author List	Rui Zhao, Jing-Jing Zhang, Siti Nurfatimah Mohd Shahpudin, Mohammad Syamsul Reza Harun, Hao-Ling Zhang and Sandai Doblin
Funding Agency and Grant Number
Corresponding Author	Sandai Doblin, Department of Biomedical Sciences, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Penang 13200, Malaysia. doblin@usm.my
Key Words	Adenosine triphosphate homeostasis; Cardiovascular disease; Cellular senescence; Regulated cell death; Purinergic signaling
Core Tip	Adenosine triphosphate (ATP) homeostasis provides an integrative framework for understanding cardiovascular cell-fate transitions by linking energy metabolism, mitochondrial function, and purinergic signaling. By distinguishing intracellular bioenergetic ATP from extracellular purinergic ATP, this review examines how ATP production, utilization, release, and clearance may shape cellular responses from reversible adaptation to senescence-associated phenotypes and regulated cell death. ATP-induced cellular senescence and ATP-induced cell death are used to describe ATP-associated cell-fate changes rather than distinct biological categories. This perspective highlights compartment-specific ATP regulation as an important area for clarifying cardiovascular disease mechanisms and for evaluating the potential translational relevance of ATP-associated metabolic regulation.
Citation	Zhao R, Zhang JJ, Mohd Shahpudin SN, Harun MSR, Zhang HL, Doblin S. Adenosine triphosphate homeostasis in cardiovascular cell-fate transitions: Adenosine triphosphate-induced cellular senescence and adenosine triphosphate-induced cell death. World J Transl Med 2026; In press DOI: https://doi.org/10.5528/wjtm.125988
PDF	125988-in-press.pdf

Received	2026-07-22 07:41
Peer-Review Started	2026-07-22 07:42
First Decision by Editorial Office Director
Return for Revision	2026-08-07 13:30
Revised	2026-08-27 13:55
Publication Fee Transferred
Second Decision by Editor	2026-10-09 03:30
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-09 09:05
Articles in Press	2026-10-09 09:05
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-6132 (online)
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