Publication Name	World Journal of Clinical Cases
Manuscript ID	126027
DOI	10.12998/wjcc.126027
Country	China

Category	Surgery
Manuscript Type	Case Report
Article Title	Multicomponent metaplastic breast cancer with four histological components: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Ting-Jun Zhao, Shi-Lei Chen, Yun-Long Zhou, Zheng-Jia Jin and Gao-Shi Huang
Funding Agency and Grant Number
Corresponding Author	Gao-Shi Huang, Department of General Surgery, The First People's Hospital of Wuyi County, No. 2 Nanmen Street, Jinhua 321200, Zhejiang Province, China. 3290029855@qq.com
Key Words	Breast; Metaplastic breast cancer; Multicomponent; Triple-negative breast cancer; Case report
Core Tip	Metaplastic breast cancer (MMBC) is a rare breast malignancy with poor prognosis and a lack of standardized treatment strategies. We report a rare case of MMBC with three invasive components plus associated ductal carcinoma in situ components, a presentation that is seldom encountered in clinical practice. The tumor exhibits a triple-negative phenotype, a high Ki-67 proliferation index, and TP53 and AKT1 gene mutations. The patient completed 8 cycles of sequential Pirarubicin plus cyclophosphamide followed by docetaxel plus cisplatin adjuvant chemotherapy, with manageable grade 2-3 adverse reactions. No local recurrence or distant metastasis was observed during the 20-month follow-up period. This case provides clinical evidence for diagnosis, individualized therapy, and prognostic evaluation of multicomponent MMBC.
Citation	Zhao TJ, Chen SL, Zhou YL, Jin ZJ, Huang GS. Multicomponent metaplastic breast cancer with four histological components: A case report. World J Clin Cases 2026; In press DOI: https://doi.org/10.12998/wjcc.126027
PDF	126027-in-press.pdf

Received	2026-07-23 09:14
Peer-Review Started	2026-07-23 09:14
First Decision by Editorial Office Director
Return for Revision	2026-08-10 06:45
Revised	2026-08-31 14:30
Publication Fee Transferred	2026-09-13 12:40
Second Decision by Editor	2026-10-09 03:30
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-09 09:10
Articles in Press	2026-10-09 09:10
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2307-8960 (online)
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