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Articles in Press
10/8/2026 8:20:57 AM | Browse: 5 | Download: 0
| Category |
Psychology, Clinical |
| Manuscript Type |
Minireviews |
| Article Title |
Brain-derived neurotrophic factor/aquaporin-4 as a target for antidepressant treatment: A minireview
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiang-Quan Song, Jian-Xiu Lai, Yi Yang, Lai-Ling Du, Ke-Wei Tian, Jing-Hua Yuan, Xin-Ling Zhang and Xiao-Ping Li |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Zhejiang Health Information Association Research Program |
No. 2025XHZN-Z04 |
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| Corresponding Author |
Xiao-Ping Li, Director, Full Professor, MD, PhD, Research Dean, Key Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Shulan International Medical College, Zhejiang Shuren University, No.8 Shuren Street, Hangzhou 310015, Zhejiang Province, China. li-xp@zjsru.edu.cn |
| Key Words |
Brain-derived neurotrophic factor Precursor brain-derived neurotrophic factor; Mature brain-derived neurotrophic factor; Aquaporin-4; Depression |
| Core Tip |
The neurotrophic hypothesis positions brain-derived neurotrophic factor (BDNF) centrally in depression pathogenesis, but upstream regulators of the precursor brain-derived neurotrophic factor (proBDNF)/mature brain-derived neurotrophic factor (mBDNF) balance remain unclear. Emerging evidence suggests astrocytic aquaporin-4 (AQP-4) modulates BDNF isoform secretion through calcium signaling and glutamate homeostasis. AQP-4 loss, mainly in cellular, animal, and postmortem studies, has been linked to increased proBDNF/mBDNF, pro-apoptotic signaling, and impaired synaptic plasticity, implying an AQP-4–BDNF axis. However, most evidence is preclinical, with limited causal data in human major depressive disorder. Thus, the AQP-4-BDNF axis is a plausible, hypothesis-generating candidate requiring further investigation, not an established therapeutic target. |
| Citation |
Song XQ, Lai JX, Yang Y, Du LL, Tian KW, Yuan JH, Zhang XL, Li XP. Brain-derived neurotrophic factor/aquaporin-4 as a target for antidepressant treatment: A minireview. World J Psychiatry 2026; In press
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Received |
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2026-07-24 07:48 |
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Peer-Review Started |
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2026-07-24 07:48 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-08-04 01:00 |
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Revised |
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2026-08-17 08:44 |
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Publication Fee Transferred |
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2026-09-17 12:30 |
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Second Decision by Editor |
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2026-10-08 07:09 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-10-08 08:20 |
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Articles in Press |
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2026-10-08 08:20 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
