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Articles in Press
10/22/2026 9:09:49 AM | Browse: 11 | Download: 1
| Category |
Oncology |
| Manuscript Type |
Minireviews |
| Article Title |
Perineural invasion in colorectal cancer surgery: From pathological finding to perioperative decision support
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Si-Jie Tang, Zi-Han Lin, Chang-Yue Liang, Yan-Dong Miao, Jie Gu and Si-Xiang Lin |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Shandong Province Medical and Health Science and Technology Development Plan Project |
No. 202203030713, No. 202303031093 |
| Shandong Province Medical and Health Science and Technology Development Plan Project |
No. 202503110210, No. 202509030205 |
| Yantai Science and Technology Program |
No. 2024YD010 |
| Science and Technology Program of Yantai Affiliated Hospital of Binzhou Medical University |
No. YTFY2022KYQD06 |
| Twenty-First Century Public Welfare Foundation Academic Research Project |
No. JJH2025001, No. JJH2025002 |
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| Corresponding Author |
Si-Xiang Lin, Chief Physician, Deputy Director, Professor, Cancer Center, Yantai Affiliated Hospital of Shandong Medical and Pharmaceutical University, The Second Clinical Medical School of Shandong Medical and Pharmaceutical University, No. 717 Jinbu Street, Muping District, Yantai 264100, Shandong Province, China. ytlsx-33@163.com |
| Key Words |
Colorectal cancer surgery; Perineural invasion; Radiomics; Artificial intelligence; Postoperative management |
| Core Tip |
Perineural invasion is an established prognostic marker, but its independent predictive value has not been demonstrated. By separating colon from rectal cancer and considering stage and neoadjuvant-treatment status, this review classifies the evidence as established, promising but unvalidated, or investigational. Clinically, perineural invasion is best interpreted together with TNM stage, lymphovascular invasion, tumor budding, molecular status, and treatment response. Depth mapping, radiomics, artificial intelligence, and biomarker approaches should remain within validation studies. |
| Citation |
Tang SJ, Lin ZH, Liang CY, Miao YD, Gu J, Lin SX. Perineural invasion in colorectal cancer surgery: From pathological finding to perioperative decision support. World J Gastrointest Surg 2026; In press
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| PDF |
126127-in-press.pdf
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Received |
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2026-07-28 07:45 |
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Peer-Review Started |
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2026-08-05 06:56 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-08-26 06:40 |
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Revised |
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2026-09-15 20:49 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-10-22 03:01 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-10-22 09:09 |
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Articles in Press |
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2026-10-22 09:09 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
