Publication Name	World Journal of Hepatology
Manuscript ID	126138
DOI	10.4254/wjh.126138
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Lipid-mediated immune reprogramming in cirrhosis-associated immune dysfunction: Mechanisms and therapeutic opportunities
Manuscript Source	Invited Manuscript
All Author List	Si-Rui Wan, Yang Song, Zeng Zhang, Pei Hao, Qing-An Xia and Kun Xia
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Fujian Province 2026J0011727
Corresponding Author	Kun Xia, PhD, Department of Gastroenterology, The National Key Clinical Specialty, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Hubin South Road, Xiamen 361004, Fujian Province, China. xiakun@stu.xmu.edu.cn
Key Words	Liver cirrhosis; Cirrhosis-associated immune dysfunction; Lipid metabolism; Immune reprogramming; Lipidomics; Immunometabolism
Core Tip	Alterations in lipid metabolism are consistently associated with cirrhosis-associated immune dysfunction, but their causal roles remain incompletely defined. This narrative review distinguishes direct cirrhosis-specific evidence - currently strongest for selected pathways such as prostaglandin E2-mediated monocyte dysfunction - from associative findings and mechanisms inferred from experimental or non-cirrhotic settings. Clarifying these levels of evidence may help guide future biomarker development and the evaluation of immunometabolism therapeutic strategies in cirrhosis.
Citation	Wan SR, Song Y, Zhang Z, Hao P, Xia QA, Xia K. Lipid-mediated immune reprogramming in cirrhosis-associated immune dysfunction: Mechanisms and therapeutic opportunities. World J Hepatol 2026; In press DOI: https://doi.org/10.4254/wjh.126138
PDF	126138-in-press.pdf

Received	2026-07-28 07:30
Peer-Review Started	2026-08-04 08:59
First Decision by Editorial Office Director
Return for Revision	2026-09-02 08:17
Revised	2026-09-04 09:31
Publication Fee Transferred
Second Decision by Editor	2026-10-26 07:15
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-26 10:23
Articles in Press	2026-10-26 10:23
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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