Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	126160
DOI	10.4251/wjgo.126160
Country	China

Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Oxaliplatin-induced pseudosepsis syndrome during FOLFOX-based hepatic arterial infusion chemotherapy for hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Hua-Yang Chen, Lin Xie, Han Qi, Shuang-Gang Chen, Yu-Jia Wang, Lu-Jun Shen, Zi-Lin Huang and Fei Cao
Funding Agency and Grant Number	Funding Agency Grant Number the National Natural Science Foundation of China 82502489
Corresponding Author	Fei Cao, Department of Minimally Invasive Interventional Therapy, Sun Yat-sen University Cancer Center, No. 651 Dongfeng East Road, Guangzhou 510060, Guangdong Province, China. caofei@sysucc.org.cn
Key Words	Oxaliplatin; Pseudosepsis; Hepatic arterial infusion chemotherapy; Hepatocellular carcinoma; Procalcitonin
Core Tip	We describe a previously underrecognized condition known as oxaliplatin-associated pseudosepsis syndrome that occurs during hepatic arterial infusion chemotherapy. It is characterized by high-grade fever, marked elevations in procalcitonin and interleukin-6 levels, transient hypotension, and occasional multiorgan dysfunction despite consistently negative blood cultures. The temporal pattern, universal recurrence upon rechallenge, and favorable response to supportive care strongly support a drug-associated inflammatory response rather than infection. Recognition of this entity is critical to avoid misdiagnosis, unnecessary antibiotic exposure, and treatment delays. In selected patients, substitution with alternative platinum agents may be considered, although further evidence is required.
Citation	Chen HY, Xie L, Qi H, Chen SG, Wang YJ, Shen LJ, Huang ZL, Cao F. Oxaliplatin-induced pseudosepsis syndrome during FOLFOX-based hepatic arterial infusion chemotherapy for hepatocellular carcinoma. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.126160
PDF	126160-in-press.pdf

Received	2026-07-27 07:06
Peer-Review Started	2026-08-05 06:25
First Decision by Editorial Office Director
Return for Revision	2026-08-20 05:44
Revised	2026-08-31 03:18
Publication Fee Transferred	2026-10-21 02:09
Second Decision by Editor	2026-11-05 03:30
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-05 08:34
Articles in Press	2026-11-05 08:34
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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