Publication Name	World Journal of Gastroenterology
Manuscript ID	126170
DOI	10.3748/wjg.126170
Country	China

Category	Oncology
Manuscript Type	Retrospective Cohort Study
Article Title	Relationship between recurrence-free survival after curative resection for hepatocellular carcinoma and prophylactic tyrosine kinase inhibitor use
Manuscript Source	Unsolicited Manuscript
All Author List	Bo-Wen Yao, Xiong He, Yu-Ze Gao, Xin-Yi Li, Wen-Wen Zheng and Cheng Guo
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82303460 Postdoctoral Research Funding Project of Shaanxi Province 2024BSHSDZZ037 Research and Development Program of Shaanxi Province 2024JC-YBQN-0897 Clinical Research Fund of the First Affiliated Hospital of Xi’an Jiaotong University XJTU1AF-CRF-2022-024
Corresponding Author	Cheng Guo, MD, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, No. 277 Yanta West Road, Xi’an 710061, Shaanxi Province, China. guocheng121@hotmail.com
Key Words	Hepatocellular carcinoma; Liver resection; Adjuvant therapy; Tyrosine kinase inhibitor; Recurrence-free survival
Core Tip	This study evaluated postoperative prophylactic sorafenib, donafenib, and lenvatinib after first R0 resection for hepatocellular carcinoma. Tyrosine kinase inhibitor (TKI) initiation was modeled as a time-dependent exposure, and 31-, 60-, and 90-day landmark, propensity-weighted, doubly robust, co-intervention, and competing-event sensitivity analyses were performed. No analysis provided clear evidence supporting routine prophylactic TKI use. The estimates remain imprecise and should not be interpreted as proof of no benefit or equivalence among agents.
Citation	Yao BW, He X, Gao YZ, Li XY, Zheng WW, Guo C. Relationship between recurrence-free survival after curative resection for hepatocellular carcinoma and prophylactic tyrosine kinase inhibitor use. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.126170
PDF	126170-in-press.pdf

Received	2026-07-27 07:15
Peer-Review Started	2026-08-04 03:02
First Decision by Editorial Office Director
Return for Revision	2026-08-24 06:51
Revised	2026-09-02 12:37
Publication Fee Transferred	2026-09-16 03:27
Second Decision by Editor	2026-10-27 03:59
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-28 10:41
Articles in Press	2026-10-28 10:41
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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