Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	126186
DOI	10.4251/wjgo.126186
Country	China

Category	Oncology
Manuscript Type	Review
Article Title	BCAT1 in colorectal cancer dissemination: Compartmentalized metabolism and the UMP-vimentin interaction
Manuscript Source	Invited Manuscript
All Author List	Lin-Feng Wang, Qiao-Yi Shen and Shao-Chun Liu
Funding Agency and Grant Number
Corresponding Author	Shao-Chun Liu, Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin Medical University, No. 150 Haping Road, Nangang District, Harbin 150081, Heilongjiang Province, China. 841915731@qq.com
Key Words	Branched-chain amino acid transaminase 1; Branched-chain amino acid transaminase 2; Colorectal cancer; Metabolic compartmentalization; Nitrogen flux; Uridine monophosphate; Vimentin; Metastasis
Core Tip	Cytosolic branched-chain amino acid transaminase (BACT) 1 links branched-chain amino acid-derived nitrogen transfer to uridine monophosphate production and vimentin stabilization in colorectal cancer cell lines and mouse dissemination models. Human tumor studies associate BCAT isoform expression with pathological features and survival. Patient-derived replication, intracellular ligand occupancy and selective intervention remain unresolved. Circulating BACT1/IKZF1 methylation assays measure tumor-associated DNA and address detection and surveillance. Connecting enzyme localization, nitrogen transfer and vimentin-dependent invasion in patient-derived tumors is the next step toward assessing therapeutic utility.
Citation	Wang LF, Shen QY, Liu SC. BCAT1 in colorectal cancer dissemination: Compartmentalized metabolism and the UMP-vimentin interaction. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.126186

Received	2026-07-28 07:45
Peer-Review Started	2026-08-05 06:56
First Decision by Editorial Office Director
Return for Revision	2026-09-01 08:39
Revised	2026-09-13 07:56
Publication Fee Transferred
Second Decision by Editor	2026-10-30 03:06
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-30 10:23
Articles in Press	2026-10-30 10:23
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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