Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	126217
DOI	10.4240/wjgs.126217
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Neoadjuvant therapy for hepatocellular carcinoma: Evolving multimodal strategies and unresolved clinical challenges
Manuscript Source	Unsolicited Manuscript
All Author List	Yi Zhou, Yan Guan, Zhi-Yong Huang and Zun-Yi Zhang
Funding Agency and Grant Number
Corresponding Author	Zun-Yi Zhang, Division of Hepato-Pancreato-Biliary Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jie Fang Avenue, Wuhan 430030, Hubei Province, China. zunyizhangtjmu@163.com
Key Words	Hepatocellular carcinoma; Neoadjuvant therapy; Multimodal treatment; Perioperative management; Major pathological response
Core Tip	Neoadjuvant therapy (NAT) is rapidly emerging as a transformative strategy in hepatocellular carcinoma (HCC) management. This minireview synthesizes current evidence across locoregional and systemic modalities, highlighting the promise of multimodal approaches in improving resectability, pathological response, and recurrence control. We identify key unresolved challenges-optimal treatment duration, surgical timing, response assessment, and patient selection-that currently limit clinical translation. By framing NAT within the evolving perioperative landscape, this review provides a roadmap for future prospective studies needed to standardize protocols and confirm survival benefits in HCC.
Citation	Zhou Y, Guan Y, Huang ZY, Zhang ZY. Neoadjuvant therapy for hepatocellular carcinoma: Evolving multimodal strategies and unresolved clinical challenges. World J Gastrointest Surg 2026; In press DOI: https://doi.org/10.4240/wjgs.126217
PDF	126217-in-press.pdf

Received	2026-07-31 03:33
Peer-Review Started	2026-08-05 03:39
First Decision by Editorial Office Director
Return for Revision	2026-08-19 06:22
Revised	2026-08-29 05:32
Publication Fee Transferred	2026-09-16 13:20
Second Decision by Editor	2026-10-13 06:01
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-13 10:02
Articles in Press	2026-10-13 10:02
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
Open Access	Open-Access: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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