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Articles in Press
10/28/2026 10:31:08 AM | Browse: 24 | Download: 7
| Category |
Oncology |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Prognostic biomarkers for pancreatic ductal adenocarcinoma: A contemporary systematic review and modelling study
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Vassiliki Tarara, Eleftherios Panteris, Sotirios Varlamis, Eleni Andreadou, Ilias Pessach, Matthaios Bobos, Maria Chatzidimitriou, Stella Mitka, Androniki Papoutsi, Phaedra Eleftheriou, Petros Skepastianos and Evangelos Karamitrousis |
| Funding Agency and Grant Number |
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| Corresponding Author |
Evangelos Karamitrousis, Assistant Professor, Department of Biomedical Sciences, International Hellenic University, Alexandria Campus, Sindos, Thessaloniki 57400, Kentrikí Makedonía, Greece. karamitrousis@ihu.gr |
| Key Words |
Pancreatic ductal adenocarcinoma; Prognostic biomarkers; Proteomics; Survival analysis; Transcriptomics |
| Core Tip |
This study integrates a contemporary systematic review with exploratory modelling to examine why prognostic biomarker discovery in pancreatic ductal adenocarcinoma has not translated into clinical practice. Although numerous tumor-derived transcriptomic and proteomic biomarkers showed independent survival associations, robust external validation and incorporation into clinical trials remained uncommon. An exploratory 5-gene molecular signature showed a strong survival association but only modest discrimination in the derivation cohort, and its continuous risk score failed external validation. These findings highlight reproducibility, prespecified validation, and biomarker-guided trial design as priorities for clinically useful pancreatic ductal adenocarcinoma risk stratification. |
| Citation |
Tarara V, Panteris E, Varlamis S, Andreadou E, Pessach I, Bobos M, Chatzidimitriou M, Mitka S, Papoutsi A, Eleftheriou P, Skepastianos P, Karamitrousis E. Prognostic biomarkers for pancreatic ductal adenocarcinoma: A contemporary systematic review and modelling study. World J Transl Med 2026; In press
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| PDF |
126295-in-press.pdf
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Received |
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2026-07-30 03:35 |
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Peer-Review Started |
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2026-08-05 00:52 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-08-27 06:48 |
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Revised |
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2026-09-20 12:20 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-10-28 07:35 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-10-28 10:31 |
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Articles in Press |
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2026-10-28 10:31 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
2220-6132 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
