Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	126397
DOI	10.4292/wjgpt.126397
Country	Singapore

Category	Surgery
Manuscript Type	Minireviews
Article Title	Histotripsy for selected gastrointestinal liver metastases: Current evidence, patient selection and responsible adoption
Manuscript Source	Invited Manuscript
All Author List	Kai Siang Chan and Vishal G Shelat
Funding Agency and Grant Number
Corresponding Author	Vishal G Shelat, Adjunct Associate Professor, Department of General Surgery, Tan Tock Seng Hospital, Singapore 308433, Singapore. vgshelat@gmail.com
Key Words	Colorectal liver metastases; Focused ultrasound; Gastrointestinal cancer; Histotripsy; Liver metastases; Liver-directed therapy; Non-thermal ablation; Surgical oncology
Core Tip	Histotripsy is a non-thermal focused-ultrasound therapy with potential value for selected gastrointestinal liver metastases that are visible on ultrasound and accessible through a safe acoustic window. Its likely role is not to replace resection, thermal ablation, stereotactic body radiation therapy, arterial therapy or systemic treatment, but to fill selected local-therapy gaps where heat, needles or radiation are undesirable. Current evidence remains early; responsible adoption requires multidisciplinary selection, standardized imaging follow-up, safety surveillance, registry capture and cost-effectiveness evaluation.
Citation	Chan KS, Shelat VG. Histotripsy for selected gastrointestinal liver metastases: Current evidence, patient selection and responsible adoption. World J Gastrointest Pharmacol Ther 2026; In press DOI: https://doi.org/10.4292/wjgpt.126397
PDF	126397-in-press.pdf

Received	2026-08-04 08:16
Peer-Review Started	2026-08-04 08:17
First Decision by Editorial Office Director
Return for Revision	2026-09-02 22:30
Revised	2026-09-13 16:32
Publication Fee Transferred
Second Decision by Editor	2026-11-09 06:26
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-09 11:21
Articles in Press	2026-11-09 11:21
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2150-5349 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com