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Articles in Press
10/16/2026 9:08:39 AM | Browse: 16 | Download: 4
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Helicobacter pylori status in gastric cancer immunotherapy: Conflicting clinical associations, immune-microbial mechanisms, and biomarker challenges
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Di Zhang, Shu-Han Li, Wei-Hao Zhang, Jun Weng, Ze-Hua Li and Kun-Hao Bai |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82403973 |
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| Corresponding Author |
Kun-Hao Bai, Associate Chief Physician, Associate Professor, MD, PhD, Department of Endoscopy, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, No. 651 Dongfengdong Street, Yuexiu District, Guangzhou 510060, Guangdong Province, China. baikh@sysucc.org.cn |
| Key Words |
Helicobacter pylori; Gastric cancer; Immune checkpoint inhibitors; Tumor immune microenvironment; Predictive biomarker |
| Core Tip |
Helicobacter pylori infection may influence gastric cancer immunotherapy outcomes, but clinical evidence remains conflicting – some studies associate positivity with poorer survival, others with enhanced benefit. This review examines the mechanistic pathways underlying this duality, including programmed cell death protein 1/programmed death-ligand 1 regulation, T-cell dysfunction, antigen presentation impairment, myeloid immunosuppression, and microbial ecological shifts. We propose that divergent findings reflect differences in infection definitions, detection methods, tumor subtypes, and treatment settings. Current evidence does not support Helicobacter pylori as a validated predictive biomarker; rather, it represents a context-dependent indicator of the tumor-immune-microbial background. Prospective studies with standardized infection definitions are critically needed. |
| Citation |
Zhang D, Li SH, Zhang WH, Weng J, Li ZH, Bai KH. Helicobacter pylori status in gastric cancer immunotherapy: Conflicting clinical associations, immune-microbial mechanisms, and biomarker challenges. World J Gastrointest Oncol 2026; In press
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| PDF |
126418-in-press.pdf
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Received |
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2026-08-04 08:16 |
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Peer-Review Started |
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2026-08-04 08:17 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-08-07 08:48 |
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Revised |
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2026-08-14 09:24 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-10-15 03:35 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-10-16 09:08 |
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Articles in Press |
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2026-10-16 09:08 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
