Publication Name	World Journal of Hepatology
Manuscript ID	126477
DOI	10.4254/wjh.126477
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Multicellular liver organoids for modeling fibrogenesis in metabolic dysfunction-associated steatohepatitis: Biological insights, current limitations, and translational perspectives
Manuscript Source	Unsolicited Manuscript
All Author List	Zi-Hao Wang
Funding Agency and Grant Number	Funding Agency Grant Number the National Undergraduate Innovation Training Program No. 202510555076
Corresponding Author	Zi-Hao Wang, Hengyang Medical School, University of South China, No. 28, Changsheng West Road, Hengyang City, Hunan Province, Hengyang 421001, Hunan Province, China. 2003000180@usc.edu.cn.
Key Words	Metabolic dysfunction-associated steatotic liver disease; Metabolic dysfunction-associated steatohepatitis; Multicellular organoids; Hepatic stellate cells; Fibrogenesis; Liver fibrosis; Disease modeling
Core Tip	Multicellular liver organoids provide human-relevant systems for studying the multicellular interactions that drive metabolic dysfunction-associated steatohepatitis-associated fibrogenesis. Their current strength lies in modeling steatotic, inflammatory, and early fibrogenic responses, whereas sustained fibrosis, tissue architecture, and standardized human-disease benchmarking remain incompletely reproduced. This review proposes a fit-for-purpose framework for selecting and interpreting these models according to the biological question and the level of validation achieved.
Citation	Wang ZH. Multicellular liver organoids for modeling fibrogenesis in metabolic dysfunction-associated steatohepatitis: Biological insights, current limitations, and translational perspectives. World J Hepatol 2026; In press DOI: https://doi.org/10.4254/wjh.126477
PDF	126477-in-press.pdf

Received	2026-08-05 03:31
Peer-Review Started	2026-08-05 03:31
First Decision by Editorial Office Director
Return for Revision	2026-08-30 10:08
Revised	2026-09-26 13:52
Publication Fee Transferred	2026-10-18 05:32
Second Decision by Editor	2026-10-27 03:59
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-28 10:39
Articles in Press	2026-10-28 10:39
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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