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Articles in Press
10/29/2026 10:26:33 AM | Browse: 3 | Download: 1
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
cfDNA methylation highlights neuro-immune crosstalk as a key correlate of pathological response to neoadjuvant immunotherapy in gastric cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Chen-Bin Lv, Lin-Yan Tong, Yi-Chen Cai, Wei-Ping Lin, Yu-Qin Sun, Yong-Bin Zhang, Wei-Ming Zeng, Li-Sheng Cai and Qiu-Xian Chen |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Fujian Province |
No. 2024J011567 |
| Climbing Project of Doctors’ Studio of Zhangzhou Hospital Affiliated to Fujian Medical University |
No. PDA202204 |
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| Corresponding Author |
Li-Sheng Cai, Department of Gastric Surgery, Zhangzhou Affiliated Hospital of Fujian Medical University, No. 59 Sheng-li Road, Zhangzhou 363000, Fujian Province, China. wxccls2024@163.com |
| Key Words |
Gastric cancer; Neoadjuvant immunotherapy; Major pathological response; Cell-free DNA methylation; Neuro-immune crosstalk |
| Core Tip |
This proof-of-concept study explored cell-free DNA methylation profiles associated with major pathological response to neoadjuvant immunotherapy in gastric cancer. CpG-island-enriched profiling identified 37185 nominally significant differentially methylated sites, of which 8904 remained significant after false discovery rate correction; functional enrichment of these false discovery rate-confirmed differentially methylated sites implicated neuroactive ligand-receptor interaction and G protein-coupled receptor signaling rather than conventional T-cell pathways. Three CpG sites were prioritized as exploratory candidates. These findings generate a testable hypothesis that baseline neuro-immune signaling may be associated with immunotherapy response through epigenetic mechanisms, offering a new biological perspective and candidate markers for future validation. |
| Citation |
Lv CB, Tong LY, Cai YC, Lin WP, Sun YQ, Zhang YB, Zeng WM, Cai LS, Chen QX. cfDNA methylation highlights neuro-immune crosstalk as a key correlate of pathological response to neoadjuvant immunotherapy in gastric cancer. World J Gastrointest Oncol 2026; In press
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| PDF |
126494-in-press.pdf
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Received |
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2026-08-06 07:21 |
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Peer-Review Started |
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2026-08-06 07:23 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-08-29 00:18 |
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Revised |
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2026-09-08 16:38 |
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Publication Fee Transferred |
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2026-09-18 01:47 |
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Second Decision by Editor |
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2026-10-29 07:08 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-10-29 10:26 |
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Articles in Press |
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2026-10-29 10:26 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
