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Articles in Press
10/30/2026 10:20:10 AM | Browse: 0 | Download: 0
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Solute carrier family 25A18 deficiency promotes cholangiocarcinoma progression and reduces gemcitabine sensitivity by impairing transforming growth factor beta receptor 1 ubiquitination and degradation
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hai-Liang Wang, Jin-Hui Wei, Jian-Jian Chen, Jiang-Yuan Huang, Peng-Cong Zheng, Yue Chen, Quan-Zhang Li, Bing-Lu Li, Shan-Zhou Huang, Chuan-Zhao Zhang, Chuan-Bao Li and Bao-Hua Hou |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Science and Technology Program of Maoming |
2024kjcxLX046 |
| the Basic and Applied Basic Research Funding Guangdong Province |
2026A1515012962 |
| the Guangdong Provincial Administration of Traditional Chinese Medicine |
202505161646276640 |
| the Funding of Weihai Central Hospital |
2023KY-02 |
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| Corresponding Author |
Bao-Hua Hou, Department of General Surgery, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, No. 2 Zhongshan Road, Guangzhou 510080, Guangdong Province, China. hbh1000@126.com |
| Key Words |
Solute carrier family 25A18; Cholangiocarcinoma; Gemcitabine sensitivity; Transforming growth factor beta receptor 1; Ubiquitination and degradation |
| Core Tip |
Solute carrier family 25A18 (SLC25A18) is downregulated in cholangiocarcinoma, and its deficiency promotes tumor progression and reduces gemcitabine sensitivity in preclinical models. Mechanistically, SLC25A18 associates with transforming growth factor beta receptor 1 (TGFBR1) and promotes its ubiquitination and proteasomal turnover, with K449 contributing to the observed ubiquitination signal. Combined SLC25A18/TGFBR1 expression provides exploratory prognostic stratification in this retrospective cohort, while its predictive and therapeutic relevance requires independent validation. |
| Citation |
Wang HL, Wei JH, Chen JJ, Huang JY, Zheng PC, Chen Y, Li QZ, Li BL, Huang SZ, Zhang CZ, Li CB, Hou BH. Solute carrier family 25A18 deficiency promotes cholangiocarcinoma progression and reduces gemcitabine sensitivity by impairing transforming growth factor beta receptor 1 ubiquitination and degradation. World J Gastroenterol 2026; In press
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Received |
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2026-08-07 03:15 |
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Peer-Review Started |
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2026-08-10 08:59 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-08-24 09:37 |
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Revised |
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2026-08-26 15:47 |
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Publication Fee Transferred |
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2026-09-14 06:30 |
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Second Decision by Editor |
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2026-10-30 08:42 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-10-30 10:20 |
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Articles in Press |
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2026-10-30 10:20 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
