Publication Name	World Journal of Hepatology
Manuscript ID	126504
DOI	10.4254/wjh.126504
Country	China

Category	Immunology
Manuscript Type	Retrospective Study
Article Title	Clinical features and associated factors for clinically significant portal hypertension in patients with histologically early-stage primary biliary cholangitis
Manuscript Source	Unsolicited Manuscript
All Author List	Hong-Xiao Hao, Xin Wei, Yao Lu, Lu Zhang, Yuan-Jiao Gao, Lei-Ping Hu, Xiao-Xue Chen, Meng-Jiao Xu, Wei-Hua Cao, Ru-Yu Liu, Ge Shen, Shu-Ling Wu, Ming-Hui Li and Yao Xie
Funding Agency and Grant Number	Funding Agency Grant Number Beijing Research Ward Excellence Program BRWEP2024W102170101 Beijing Municipal Health Commission High-Level Public Health Technical Personnel Construction Project discipline leader-03-26 Beijing Hospitals Authority Clinical Medicine Development of Special Funding Support ZLRK202301 Beijing Hospitals Authority “Peak” Talent Training Program DFL20241803 National Key Research and Development Program of China 2023YFC2306900 National Key Research and Development Program of Ministry of Science and Technology 2023YFC2308105
Corresponding Author	Ming-Hui Li, PhD, Professor, Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Peking University Ditan Teaching Hospital, No. 8 Jingshun East Street, Chaoyang District, Beijing 100015, China. wuhm2000@sina.com
Key Words	Primary biliary cholangitis; Histologically early-stage; Portal Hypertension; Clinically significant portal hypertension; Autoimmune liver disease; Associated factors; Retrospective studies
Core Tip	In early-stage primary biliary cholangitis, pre-cirrhotic clinically significant portal hypertension was common (24.5%). Drug-allergy history and wider main portal vein were independent risk factors, suggesting simple clues for risk stratification. However, the single-center retrospective design, modest sample, lack of hepatic venous pressure gradient (HVPG) confirmation, and short follow-up limit causal and prognostic inference. Routine care should include allergy history and ultrasound portal-vein monitoring; multicenter prospective HVPG-based studies are needed to validate prediction models.
Citation	Hao HX, Wei X, Lu Y, Zhang L, Gao YJ, Hu LP, Chen XX, Xu MJ, Cao WH, Liu RY, Shen G, Wu SL, Li MH, Xie Y. Clinical features and associated factors for clinically significant portal hypertension in patients with histologically early-stage primary biliary cholangitis. World J Hepatol 2026; In press DOI: https://doi.org/10.4254/wjh.126504
PDF	126504-in-press.pdf

Received	2026-08-06 06:29
Peer-Review Started	2026-08-06 06:29
First Decision by Editorial Office Director
Return for Revision	2026-08-14 07:07
Revised	2026-08-28 02:18
Publication Fee Transferred	2026-09-13 11:24
Second Decision by Editor	2026-11-09 06:25
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-09 11:21
Articles in Press	2026-11-09 11:21
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com