Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	126515
DOI	10.4251/wjgo.126515
Country	China

Category	Oncology
Manuscript Type	Case Report
Article Title	Antibody-drug conjugates induced a durable response in trastuzumab-resistant HER2-positive gastric cancer: A case report and review of literature
Manuscript Source	Unsolicited Manuscript
All Author List	Jin-Hui Zhang, Chang-Jing Cai, Shan Zeng, Feng Zhao, Li Wang and Li-Dan Wu
Funding Agency and Grant Number
Corresponding Author	Li-Dan Wu, Professor, Teaching and Research Section of Clinical Nursing, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha 410008, Hunan Province, China. 15074986040@163.com
Key Words	Gastric cancer; Trastuzumab-resistant; Antibody-drug conjugates; Immune checkpoint inhibition; Liver metastasis; Durable response; Case report
Core Tip	First-line treatment for human epidermal growth factor receptor 2 (HER2)-positive advanced gastric cancer (GC) is primarily based on chemotherapy combined with trastuzumab. However, the median overall survival of advanced GC is only about 12 months. No standard consensus second-line treatment has been established for patients with HER2-positive advanced GC following progression on trastuzumab-based therapy. This case achieved a complete response and durable survival following treatment with HER2-targeted antibody-drug conjugates in combination with immunotherapy. This case highlights the potential therapeutic value of this combination strategy and provides additional real-world evidence to support its use in trastuzumab-resistant HER2-positive advanced GC.
Citation	Zhang JH, Cai CJ, Zeng S, Zhao F, Wang L, Wu LD. Antibody-drug conjugates induced a durable response in trastuzumab-resistant HER2-positive gastric cancer: A case report and review of literature. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.126515
PDF	126515-in-press.pdf

Received	2026-08-07 03:03
Peer-Review Started	2026-08-07 03:03
First Decision by Editorial Office Director
Return for Revision	2026-09-04 16:36
Revised	2026-09-23 15:17
Publication Fee Transferred	2026-10-19 15:22
Second Decision by Editor	2026-11-02 02:18
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-04 10:46
Articles in Press	2026-11-04 10:46
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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